Puurunen J
Department of Pharmacology and Toxicology, University of Oulu, Finland.
Naunyn Schmiedebergs Arch Pharmacol. 1988 Jul;338(1):96-8. doi: 10.1007/BF00168818.
Administration of 10-100 micrograms of histamine into the lateral cerebral ventricle of anaesthetized rats stimulated gastric acid secretion in a dose-dependent manner, while subcutaneous (s.c.) injections of the same doses produced clearly less pronounced increases in the acid output. In vagotomized rats only a marginal response to histamine given into the lateral ventricle was observed. When injected into the third cerebral ventricle the doses of histamine needed for the stimulation of gastric acid secretion were 1-10 micrograms, the effect being totally abolished by vagotomy. The results indicate that histamine is capable of stimulating gastric acid secretion by a central, vagal-dependent mechanism.
向麻醉大鼠的侧脑室注射10 - 100微克组胺，可剂量依赖性地刺激胃酸分泌，而皮下注射相同剂量组胺时，胃酸分泌的增加明显不那么显著。在迷走神经切断的大鼠中，仅观察到对注入侧脑室的组胺有轻微反应。当注入第三脑室时，刺激胃酸分泌所需的组胺剂量为1 - 10微克，迷走神经切断可完全消除这种作用。结果表明，组胺能够通过一种中枢性、依赖迷走神经的机制刺激胃酸分泌。
