[STAT6免疫组化在孤立性纤维性肿瘤/脑膜血管外皮细胞瘤中的诊断价值]

[Diagnostic value of STAT6 immunohistochemistry in solitary fibrous tumor/meningeal hemangiopericytoma].

作者信息

Zhang Xialing, Cheng Haixia, Bao Yun, Tang Feng, Wang Yin

机构信息

Department of Pathology, Huashan Hospital, Fudan University, Shanghai 200040, China.

出版信息

Zhonghua Bing Li Xue Za Zhi. 2016 Feb;45(2):97-101. doi: 10.3760/cma.j.issn.0529-5807.2016.02.006.

DOI:10.3760/cma.j.issn.0529-5807.2016.02.006

PMID:26879430

Abstract

OBJECTIVE

To investigate the diagnostic role of STAT6 immunohistochemistry in solitary fibrous tumors (SFT)/meningeal hemangiopericytomas (HPC).

METHOD

Evaluated the expression of STAT6, vimentin, CD34, EMA, PR, S-100, CD56, GFAP and Ki-67 in a cohort of 37 SFT/meningeal HPC, 30 meningiomas and 30 schwannomas by immunohistochemistry staining.

RESULTS

All SFT/meningeal HPC demonstrated nuclear positivity for STAT6, and the proportion of positive tumor cells ranged from 60% to 95%, with no significant difference cases.Vimentin was strongly positive in all cases. CD34, EMA and PR positivity was found in 32 cases, 1 case and 4 cases, respectively.S-100 protein, CD56 and GFAP were negative; Ki-67 labeling index was 1%-8%. However, the meningiomas and schwannomas were negative for STAT6.

CONCLUSIONS

STAT6 is a relatively specific biomarker for SFT/meningeal HPC, and may be used in the diagnosis and differential diagnosis of SFT/meningeal HPC, especially for the atypical cases, and allows the precise pathologic diagnosis of SFT/meningeal HPC.

摘要

目的

探讨信号转导和转录激活因子6（STAT6）免疫组化在孤立性纤维性肿瘤（SFT）/脑膜血管外皮细胞瘤（HPC）中的诊断作用。

方法

采用免疫组化染色法评估37例SFT/脑膜HPC、30例脑膜瘤和30例神经鞘瘤中STAT6、波形蛋白、CD34、上皮膜抗原（EMA）、孕激素受体（PR）、S-100、CD56、胶质纤维酸性蛋白（GFAP）和Ki-67的表达情况。

结果

所有SFT/脑膜HPC的STAT6均呈细胞核阳性，阳性肿瘤细胞比例为60%至95%，各病例间无显著差异。波形蛋白在所有病例中均呈强阳性。CD34、EMA和PR阳性分别见于32例、1例和4例。S-100蛋白、CD56和GFAP均为阴性；Ki-67标记指数为1%至8%。然而，脑膜瘤和神经鞘瘤的STAT6呈阴性。