Inoue S, Hasegawa K, Nakamura T, Nezuo S, Kawahara Y, Tadaoka S, Kakumae S, Sawayama T
Kokyu To Junkan. 1989 Oct;37(10):1143-6.
A 47-year-old man, with dilated cardiomyopathy developed severe hyponatremia and hypoosmolarity during captopril therapy. He also had an inappropriate elevation of antidiuretic hormone and urine osmolarity, but no evidence of dehydration, renal or suprarenal disturbances. The hyponatremia and hypoosmolarity improved after withdrawal of captopril alone, and recurred after readministration of captopril. We conclude that the hyponatremia may be caused by high secretion of prostagrandin and bradykinin associated with captopril therapy.
一名47岁男性，患有扩张型心肌病，在卡托普利治疗期间出现严重低钠血症和低渗血症。他还存在抗利尿激素和尿渗透压不适当升高的情况，但没有脱水、肾脏或肾上腺功能紊乱的证据。仅停用卡托普利后，低钠血症和低渗血症有所改善，再次服用卡托普利后又复发。我们得出结论，低钠血症可能是由与卡托普利治疗相关的前列腺素和缓激肽高分泌引起的。
