State Key Lab of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, Jilin, China.
College of Chemistry, Sichuan University, Chengdu 610064, Sichuan, China.
Nanoscale. 2016 Mar 7;8(9):5260-7. doi: 10.1039/c5nr07723k.
The integration of phototherapy and chemotherapy in a single system holds great promise to improve the therapeutic efficacy of tumor treatment, but it remains a key challenge. In this study, we describe our recent finding that polycatechol nanosheet (PCCNS) can be facilely prepared on a large scale via chemical polymerization at 4 °C, as an effective nanocarrier for loading high-density CuS nanocrystals as a photothermal agent. The resulting CuS/PCCNS nanocomposites exhibit good biocompatibility, strong stability, and a high photothermal conversion efficiency of ∼45.7%. The subsequent loading of anticancer drug doxorubicin (Dox) creates a superior theranostic agent with pH- and heat-responsive drug release, leading to almost complete destruction of mouse cervical tumor under NIR laser irradiation. This development offers an attractive theranostic agent for in vivo chemo-photothermal synergistic therapy toward biomedical applications.
光疗和化疗的整合在单一系统中具有很大的潜力，可以提高肿瘤治疗的疗效，但这仍然是一个关键的挑战。在这项研究中，我们描述了我们最近的发现，即儿茶酚纳米片（PCCNS）可以通过在 4°C 下的化学聚合轻易地大规模制备，作为负载高密度 CuS 纳米晶作为光热剂的有效纳米载体。所得的 CuS/PCCNS 纳米复合材料具有良好的生物相容性、强稳定性和高达 45.7%的高光热转换效率。随后负载抗癌药物阿霉素（Dox），创造了一种具有 pH 和热响应药物释放的优越治疗剂，在近红外激光照射下几乎完全破坏了小鼠宫颈肿瘤。这种发展为体内化学-光热协同治疗提供了一种有吸引力的治疗剂，用于生物医学应用。
