Zhou Shu-Mei, Ma De-Kun, Zhang Sheng-Hui, Wang Wei, Chen Wei, Huang Shao-Ming, Yu Kang
Nanomaterials and Chemistry Key Laboratory, Wenzhou University, Wenzhou, Zhejiang 325027, P. R. China.
Department of Hematology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325027, P. R. China.
Nanoscale. 2016 Jan 21;8(3):1374-82. doi: 10.1039/c5nr06041a.
Developing multifunctional near-infrared (NIR) light-driven photothermal agents is in high demand for efficient cancer therapy. Herein, PEGylated Cu3BiS3 hollow nanospheres (HNSs) with an average diameter of 80 nm were synthesized through a facile ethylene glycol-mediated solvothermal route. The obtained PEGylated Cu3BiS3 HNSs exhibited strong NIR optical absorption with a large molar extinction coefficient of 4.1 × 10(9) cm(-1) M(-1) at 980 nm. Under the irradiation of a 980 nm laser with a safe power density of 0.72 W cm(-2), Cu3BiS3 HNSs produced significant photothermal heating with a photothermal transduction efficiency of 27.5%. The Cu3BiS3 HNSs also showed a good antitumoral drug doxorubicin (DOX) loading capacity and pH- and NIR-responsive DOX release behaviors. At a low dosage of 10 μg mL(-1), HeLa cells could be efficiently killed through a synergistic effect of chemo- and photothermo-therapy respectively based on the DOX release and the photothermal effect of Cu3BiS3 HNSs. In addition, Cu3BiS3 HNSs displayed a good X-ray computed tomography (CT) imaging capability. Furthermore, Cu3BiS3 HNSs could be used for efficient in vivo photothermochemotherapy and X-ray CT imaging of mice bearing melanoma skin cancer. This multifunctional theranostic nanomaterial shows potential promise for cancer therapy.
开发多功能近红外（NIR）光驱动的光热剂对于高效癌症治疗具有很高的需求。在此，通过简便的乙二醇介导的溶剂热法合成了平均直径为80nm的聚乙二醇化Cu3BiS3空心纳米球（HNSs）。所获得的聚乙二醇化Cu3BiS3 HNSs在980nm处表现出强烈的近红外光吸收，摩尔消光系数大，为4.1×10(9) cm(-1) M(-1)。在功率密度为0.72 W cm(-2)的安全980nm激光照射下，Cu3BiS3 HNSs产生显著的光热加热，光热转换效率为27.5%。Cu3BiS3 HNSs还表现出良好的抗肿瘤药物阿霉素（DOX）负载能力以及pH和近红外响应的DOX释放行为。在低剂量10μg mL(-1)时，基于DOX释放和Cu3BiS3 HNSs的光热效应，通过化学疗法和光热疗法的协同作用可有效杀死HeLa细胞。此外，Cu3BiS3 HNSs显示出良好的X射线计算机断层扫描（CT）成像能力。此外，Cu3BiS3 HNSs可用于荷黑色素瘤皮肤癌小鼠的高效体内光热化疗和X射线CT成像。这种多功能治疗诊断纳米材料在癌症治疗方面显示出潜在的前景。
