Wang He, Liu Yali, Chen Sharon C-A, Long Yun, Kong Fanrong, Xu Ying-Chun
Department of Clinical Laboratory, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, China; Graduate School, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, China.
Department of Clinical Laboratory, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, China.
J Microbiol Immunol Infect. 2016 Apr;49(2):281-5. doi: 10.1016/j.jmii.2015.12.011. Epub 2016 Jan 15.
Chaetomium atrobrunneum has never been reported to be associated with pneumonia. We report the isolation of C. atrobrunneum and Aspergillus fumigatus from a Chinese elderly patient with fatal pneumonia. Branched, long, and septate hyphae were observed in potassium hydroxide preparations and Gram-stained smears, and confluent C. atrobrunneum growth and a few A. fumigatus colonies were found in tracheal aspirates (nine separate occasions). These isolates were identified by conventional morphological methods and by sequencing the internal transcribed spacer and the D1/D2 domain of the 26S rRNA gene. The patient responded poorly to the combination therapy of amphotericin B and caspofungin. This report adds C. atrobrunneum to the list of fungal pneumonia in immunocompromised hosts. This case report also illustrated the presence of a growth symbiosis between Chaetomium species and A. fumigatus.
深褐毛壳菌从未被报道与肺炎相关。我们报告了从一名患有致命肺炎的中国老年患者中分离出深褐毛壳菌和烟曲霉。在氢氧化钾制剂和革兰氏染色涂片中观察到分支、长且有隔膜的菌丝，并且在气管吸出物中发现了融合的深褐毛壳菌生长和少量烟曲霉菌落（9次独立观察）。这些分离株通过传统形态学方法以及对26S rRNA基因的内部转录间隔区和D1/D2结构域进行测序来鉴定。该患者对两性霉素B和卡泊芬净联合治疗反应不佳。本报告将深褐毛壳菌添加到免疫功能低下宿主的真菌性肺炎名单中。该病例报告还说明了毛壳菌属物种与烟曲霉之间存在生长共生关系。
