用双刃剑“避免”伤害：超滤在心力衰竭中能发挥作用吗？

"AVOID"ing harm by a double-edged sword: is there a role for ultrafiltration in heart failure?

作者信息

Kazory Amir

机构信息

Division of Nephrology, Hypertension, and Renal Transplantation, University of Florida, Gainesville, Florida, USA.

出版信息

Kidney Int. 2016 Mar;89(3):527-8. doi: 10.1016/j.kint.2016.01.002.

DOI:10.1016/j.kint.2016.01.002

PMID:26880445

Abstract

Prior studies comparing ultrafiltration with medical management for acute decompensated heart failure have yielded conflicting results. The AVOID-HF trial was designed as a definitive comparison of optimal ultrafiltration versus optimal diuretic-based medical therapy; unfortunately, the trial was terminated prematurely because of slow recruitment. The results of AVOID-HF nevertheless provide a rationale for well-designed, adequately powered trials to determine whether ultrafiltration has a role in the routine management of acute decompensated heart failure.

摘要

先前比较超滤与药物治疗急性失代偿性心力衰竭的研究结果相互矛盾。AVOID-HF试验旨在对最佳超滤与基于利尿剂的最佳药物治疗进行明确比较；不幸的是，由于入组缓慢，该试验提前终止。尽管如此，AVOID-HF试验的结果为设计良好、样本量充足的试验提供了理论依据，以确定超滤在急性失代偿性心力衰竭的常规管理中是否发挥作用。