Carron Sophie, Bloemen Maarten, Vander Elst Luce, Laurent Sophie, Verbiest Thierry, Parac-Vogt Tatjana N
Department of Chemistry, KU Leuven, Celestijnenlaan 200F/200D, 3001, Leuven, Belgium.
Department of General, Organic and Biomedical Chemistry, University of Mons, Place du Parc 23, 7000, Mons, Belgium.
Chemistry. 2016 Mar 18;22(13):4521-7. doi: 10.1002/chem.201504731. Epub 2016 Feb 16.
A new prototype consisting of ultrasmall superparamagnetic iron oxide (USPIO) nanoparticles decorated with europium(III) ions encapsulated in a DO3A organic scaffold was designed as a platform for further development of bimodal contrast agents for MRI and optical imaging. The USPIO nanoparticles act as negative MRI contrast agents, whereas the europium(III) ion is a luminophore that is suitable for use in optical imaging detection. The functionalized USPIO nanoparticles were characterized by TEM, DLS, XRD, FTIR, and TXRF analysis, and a full investigation of the relaxometric and optical properties was conducted. The typical luminescence emission of europium(III) was observed and the main red emission wavelength was found at 614 nm. The relaxometric study of these ultrasmall nanoparticles showed r2 values of 114.8 mM(-1) Fes(-1) at 60 MHz, which is nearly double the r2 relaxivity of Sinerem(®).
设计了一种新型原型，它由超小超顺磁性氧化铁（USPIO）纳米颗粒组成，这些纳米颗粒装饰有包裹在DO3A有机支架中的铕（III）离子，作为进一步开发用于MRI和光学成像的双模态造影剂的平台。USPIO纳米颗粒用作阴性MRI造影剂，而铕（III）离子是一种适用于光学成像检测的发光体。通过透射电子显微镜（TEM）、动态光散射（DLS）、X射线衍射（XRD）、傅里叶变换红外光谱（FTIR）和全反射X射线荧光光谱（TXRF）分析对功能化的USPIO纳米颗粒进行了表征，并对弛豫和光学性质进行了全面研究。观察到了铕（III）的典型发光发射，发现主要红色发射波长为614nm。对这些超小纳米颗粒的弛豫研究表明，在60MHz时r2值为114.8 mM(-1) Fes(-1)，这几乎是Sinerem®的r2弛豫率的两倍。
