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不同类风湿关节炎患者组的治疗概况:描述、分析、评估。

Treatment profiles in different groups of RA-sufferers: description, analysis, evaluation.

作者信息

Raspe H H, Mau W, Wasmus A

机构信息

Department of Rheumatology, Hannover Medical School, FRG.

出版信息

Scand J Rheumatol Suppl. 1989;79:57-65. doi: 10.3109/03009748909092613.

Abstract

(1) 50 to 80% of all rA-sufferers treated by rheumatologists have received second line therapy in contrast to 7 to 27% at the community level. (2) Disease duration and disease activity do not seem to affect the treatment regimens of primary and other physicians working in or around Hannover. The same holds true for social and demographic characteristics of the patients. (3) RA-sufferers are generally undertreated by community based doctors with regard to RiD-therapy and disease activity. Approximately 80% of patients with formal indication for the use of RiDs have not received these drugs, despite the fact that a rheumatological department with an outpatient clinic providing more than 3500 consultations per year has existed for more than 20 years at the Medizinische Hochschule Hannover. This outpatient clinic is utilized by more than 60% of all general practitioners as well as internal and orthopedic physicians working in the city of Hannover. We thus have to admit a rather low community effectiveness of our service. (4) A sensitivity of the formal evaluation-scheme of 0.70 and a specificity of 0.80 imply 30% false-negative and 20% false-positive assessments. In view of the larger number of false-negative judgements one must assume an even greater difference between treatment-reality and rheumatological concepts. (5) Sofar we cannot offer any safe explanation for the reasons underlying this unsatisfactory situation. The predictors we have investigated up to now have not proven to be selective. (6) Nevertheless, practical steps are urgently required, in order to be rheumatologically more effective at the community level--at least in Hannover/FRG.

摘要

(1) 由风湿病专家治疗的所有类风湿性关节炎(rA)患者中,50%至80%接受了二线治疗,而在社区层面这一比例为7%至27%。(2) 疾病持续时间和疾病活动度似乎并不影响在汉诺威市内或周边工作的初级医生和其他医生的治疗方案。患者的社会和人口统计学特征也是如此。(3) 在缓解病情抗风湿药(RiD)治疗和疾病活动度方面,社区医生对类风湿性关节炎患者的治疗普遍不足。尽管汉诺威医学院有一个每年提供超过3500次门诊咨询的风湿病科已经存在了20多年,但约80%有使用RiD正式指征的患者并未接受这些药物治疗。汉诺威市超过60%的全科医生以及内科和骨科医生都利用这个门诊。因此,我们不得不承认我们服务的社区有效性相当低。(4) 正式评估方案的敏感度为0.70,特异度为0.80,这意味着有30%的假阴性和20%的假阳性评估。鉴于假阴性判断数量较多,必须假定治疗现实与风湿病学概念之间存在更大差异。(5) 到目前为止,我们无法对这种不令人满意的情况背后的原因提供任何合理的解释。我们目前所研究的预测因素尚未被证明具有选择性。(6) 然而,迫切需要采取实际措施,以便在社区层面在风湿病学方面更有成效——至少在汉诺威/联邦德国。

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