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[活动性慢性多关节炎患者接受“基础治疗”了吗?]

[Do patients with active chronic polyarthritis get "basic therapy"?].

作者信息

Raspe H H, Wasmus A

机构信息

Abteilung Rheumatologie, Medizinische Hochschule Hannover.

出版信息

Soz Praventivmed. 1988;33(4-5):197-201. doi: 10.1007/BF02083573.

Abstract

The determination of the adequacy of an individual therapeutical regimen is part of the process evaluation of medical care. To evaluate the adequacy of individual antirheumatic therapy, we developed a five step procedure: 1. Assessment of the patient's health status; 2. assessment of his/her former and current therapy; 3. determination of the adequate antirheumatic therapy following an explicit norm; 4. formal comparison of current and adequate treatment; 5. clinical evaluation of possible differences between norm and reality. Due to methodological reasons we concentrated on the current treatment of rheumatoid arthritis (rA) patients with remission inducing drugs (RIDs; e.g. Chloroquine, Gold). The study analyzed the RID treatment of 75 rA-sufferers; 25 patients were referred to our outpatient department for the first time in late 1986; 25 patients were recruited from a social-medical study covering employed but actually disabled members of a major health insurance (AOK) in Hannover; 25 subjects were derived from an ongoing population study ("prevalence and care of rheumatoid arthritis in Hannover"). Only 9 out of 49 (18%) patients with an active disease, formally in need of treatment, were currently treated with RIDs. Thus 40 out of 49 (82%) seemed to be under an inadequate treatment. From the clinical point of view this formal judgement was assumed to be false positive in 5 and false negative in 15 cases. In relation to the clinical judgements we found for the formal procedure a sensitivity of 0.70 with a specificity of 0.80 and an overall agreement of 73% (kappa 0.44).

摘要

确定个体治疗方案是否恰当是医疗过程评估的一部分。为评估个体抗风湿治疗的恰当性,我们制定了一个五步程序:1. 评估患者的健康状况;2. 评估其既往和当前的治疗;3. 根据明确的标准确定恰当的抗风湿治疗;4. 对当前治疗与恰当治疗进行正式比较;5. 对标准与实际情况之间可能存在的差异进行临床评估。由于方法学原因,我们专注于类风湿关节炎(RA)患者使用缓解诱导药物(RIDs;如氯喹、金制剂)的当前治疗。该研究分析了75例RA患者的RIDs治疗情况;25例患者于1986年末首次被转诊至我们的门诊部;25例患者是从一项社会医学研究中招募的,该研究涵盖了汉诺威一家大型健康保险机构(AOK)中就业但实际残疾的成员;25例受试者来自一项正在进行的人群研究(“汉诺威类风湿关节炎的患病率与治疗”)。在49例患有活动性疾病、正式需要治疗的患者中,目前仅有9例(18%)接受RIDs治疗。因此,49例中有40例(82%)似乎接受了不恰当的治疗。从临床角度来看,这种正式判断在5例中被认为是假阳性,在15例中被认为是假阴性。相对于临床判断,我们发现正式程序的敏感性为0.70,特异性为0.80,总体一致性为73%(kappa值为0.44)。

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