Chen Zhitao, Wu Jie, Xu Dan, Huang Manling, Sun Shengbin, Zhang Heng, Huang Xiaodong, Wang Ping
Department of Gastroenterology and Central Laboratory, Central Hospital of Wuhan, Wuhan, China.
Department of Gastroenterology and Central Laboratory, Central Hospital of Wuhan, Wuhan, China
J Int Med Res. 2016 Apr;44(2):241-7. doi: 10.1177/0300060515611535. Epub 2016 Feb 15.
To investigate levels of epidermal growth factor (EGF) and prostaglandin E2 (PGE2) in Han Chinese patients with Helicobacter pylori-positive gastric low-grade intraepithelial neoplasia (LGIN).
In this prospective, observational study, gastric specimens from patients with LGIN were collected by gastroscopy with consecutive biopsy. EGF and PGE2 concentrations in serum and gastric juice from patients with LGIN were measured by enzyme-linked immunosorbent assay. Presence of H. pylori infection was assessed in patients with LGIN and healthy controls.
Out of 5 638 patients and 548 controls, H. pylori infection in patients with chronic gastritis was associated with disease type (endoscopic classification) and disease severity. Patients with H. pylori-positive LGIN had significantly higher concentrations of serum EGF and lower concentrations of serum PGE2 versus patients with H. pylori-negative LGIN. Serum EGF and PGE2 levels in patients with LGIN were not significantly associated with disease type, but were significantly associated with disease severity.
H. pylori infection was associated with chronic gastritis type (endoscopic classification) and disease severity. Abnormal EGF and PGE2 levels may be associated with H. pylori-positive LGIN in Han Chinese patients in central China.
研究中国汉族幽门螺杆菌阳性胃低级别上皮内瘤变（LGIN）患者的表皮生长因子（EGF）和前列腺素E2（PGE2）水平。
在这项前瞻性观察研究中，通过胃镜连续活检收集LGIN患者的胃标本。采用酶联免疫吸附测定法测量LGIN患者血清和胃液中EGF和PGE2的浓度。评估LGIN患者和健康对照者中幽门螺杆菌感染情况。
在5638例患者和548例对照中，慢性胃炎患者的幽门螺杆菌感染与疾病类型（内镜分类）和疾病严重程度相关。与幽门螺杆菌阴性LGIN患者相比，幽门螺杆菌阳性LGIN患者的血清EGF浓度显著更高，血清PGE2浓度更低。LGIN患者的血清EGF和PGE2水平与疾病类型无显著相关性，但与疾病严重程度显著相关。
幽门螺杆菌感染与慢性胃炎类型（内镜分类）和疾病严重程度相关。在中国中部汉族患者中，EGF和PGE2水平异常可能与幽门螺杆菌阳性LGIN有关。
