造血干细胞：多参数调节
Hematopoietic stem cells: multiparameter regulation.
作者信息
Song Kedong, Li Liying, Wang Yiwei, Liu Tianqing
机构信息
State Key Laboratory of Fine Chemicals, Dalian R&D Center for Stem Cell and Tissue Engineering, Dalian University of Technology, Dalian, 116024, China.
Burns Research Group, ANZAC Research Institute, University of Sydney, Concord, NSW, 2139, Australia.
出版信息
Hum Cell. 2016 Apr;29(2):53-7. doi: 10.1007/s13577-016-0134-x. Epub 2016 Feb 16.
Hematopoietic stem cells (HSCs) are capable to self-renew with multi-potency which generated much excitement in clinical therapy. However, the main obstacle of HSCs in clinical application was insufficient number of HSCs which were derived from either bone marrow, peripheral blood or umbilical cord blood. This review briefly discusses the indispensable utility of growth factors and cytokines, stromal cells, extracellular matrix, bionic scaffold and microenvironment aiming to control the hematopoiesis in all directions and provide a better and comprehensive understanding for in vitro expansion of hematopoietic stem cells.
造血干细胞（HSCs）具有自我更新和多能性，这在临床治疗中引起了极大的关注。然而，造血干细胞在临床应用中的主要障碍是其数量不足，这些造血干细胞来源于骨髓、外周血或脐带血。本文简要讨论了生长因子和细胞因子、基质细胞、细胞外基质、仿生支架和微环境在全方位控制造血过程中的不可或缺的作用，旨在为造血干细胞的体外扩增提供更全面、深入的理解。
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