Department of Biochemistry, BK21 PLUS Program for Creative Veterinary Science Research and Research Institute for Veterinary Science, College of Veterinary Medicine, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul, 151-742, South Korea.
Cell Biol Toxicol. 2020 Apr;36(2):131-144. doi: 10.1007/s10565-019-09510-7. Epub 2020 Jan 2.
Hematopoietic stem cells (HSCs) produce new blood cells everyday throughout life, which is maintained by the self-renewal and differentiation ability of HSCs. This is not controlled by the HSCs alone, but rather by the complex and exquisite microenvironment surrounding the HSCs, which is called the bone marrow niche and consists of various bone marrow cells, growth factors, and cytokines. It is essential to understand the characteristic role of the stem cell niche and the growth factors in the niche formation. In this review, we describe the role of the bone marrow niche and factors for niche homeostasis, and also summarize the latest research related to stem cell niche.
造血干细胞（HSCs）在整个生命过程中每天都会产生新的血细胞，这是由 HSCs 的自我更新和分化能力维持的。这不仅由 HSCs 自身控制，还由 HSCs 周围复杂而精细的微环境控制，这个微环境被称为骨髓龛，由各种骨髓细胞、生长因子和细胞因子组成。了解干细胞龛和龛内生长因子的特征作用至关重要。在这篇综述中，我们描述了骨髓龛和维持龛内环境稳定的因素的作用，并总结了与干细胞龛相关的最新研究。
