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两种基于紫杉醇的乳腺癌辅助化疗标准治疗方案的毒性特征和耐受性比较。

Comparison of toxicity profile and tolerability between two standard of care paclitaxel-based adjuvant chemotherapy regimens in breast cancer.

作者信息

Alsharedi Mohamed, Gress Todd, Dotson Jennifer, Elmsherghi Nabiha, Tirona Maria Tria

机构信息

Division of Hematology and Oncology, Edwards Comprehensive Cancer Center at Cabell Huntington Hospital, Joan C. Edwards School of Medicine, Marshall University, 1400 Hal Greer Blvd., Huntington, WV, 25701, USA.

出版信息

Med Oncol. 2016 Mar;33(3):27. doi: 10.1007/s12032-016-0740-1. Epub 2016 Feb 16.

Abstract

In breast cancer, there are two widely used paclitaxel-based adjuvant chemotherapies, either dose dense paclitaxel (ddP) or weekly paclitaxel (wP). To our knowledge, the comparisons of toxicity and tolerability between the two regimens have never been reported in the literature. This is a retrospective single-institution charts review of breast cancer patients who were treated with paclitaxel-based chemotherapy either ddP or wP. In total, 76 and 45 patients with breast cancer received adjuvant standard ddP and wP, respectively. Patient characteristics in both groups were comparable. Our results showed no statistical significant difference in toxicity profile and tolerability between the two regimens. Particularly, chemotherapy-induced peripheral neuropathy (CIPN) was equally observed in both schedules. Furthermore, grade 3 and 4 CIPN was observed in 17 and 18 %, respectively (p = 0.93). In terms of tolerability, both regimens resulted in similar rates of hospitalization and treatment discontinuation. Our data analysis indicates no significant difference in toxicity profile between the two standard paclitaxel regimens in breast cancer. However, this is a small sample-sized retrospective study and further prospective trial with a larger sample size is warranted.

摘要

在乳腺癌治疗中,有两种广泛使用的基于紫杉醇的辅助化疗方案,即剂量密集型紫杉醇(ddP)或每周紫杉醇(wP)。据我们所知,两种方案之间毒性和耐受性的比较在文献中从未报道过。这是一项对接受基于紫杉醇化疗(ddP或wP)的乳腺癌患者进行的单机构回顾性病历审查。共有76例和45例乳腺癌患者分别接受了辅助标准ddP和wP治疗。两组患者的特征具有可比性。我们的结果显示,两种方案在毒性特征和耐受性方面无统计学显著差异。特别是,两种方案中化疗引起的周围神经病变(CIPN)发生率相当。此外,3级和4级CIPN分别在17%和18%的患者中观察到(p = 0.93)。在耐受性方面,两种方案导致的住院率和治疗中断率相似。我们的数据分析表明,两种标准紫杉醇方案在乳腺癌中的毒性特征无显著差异。然而,这是一项小样本的回顾性研究,有必要进行更大样本量的进一步前瞻性试验。

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