Carroll J S
Cancer Research UKCambridge Institute, University of Cambridge, Cambridge, UK
Eur J Endocrinol. 2016 Jul;175(1):R41-9. doi: 10.1530/EJE-16-0124. Epub 2016 Feb 16.
Most breast cancers are driven by a transcription factor called oestrogen receptor (ER). Understanding the mechanisms of ER activity in breast cancer has been a major research interest and recent genomic advances have revealed extraordinary insights into how ER mediates gene transcription and what occurs during endocrine resistance. This review discusses our current understanding on ER activity, with an emphasis on several evolving, but important areas of ER biology.
大多数乳腺癌是由一种名为雌激素受体（ER）的转录因子驱动的。了解ER在乳腺癌中的活性机制一直是主要的研究兴趣所在，最近的基因组学进展为ER如何介导基因转录以及内分泌抵抗期间发生了什么提供了非凡的见解。本综述讨论了我们目前对ER活性的理解，重点关注ER生物学中几个不断发展但重要的领域。
Zotero 插件