使用定量脑电图分析评估双相I型心境障碍（BMD I）与双相II型心境障碍（BMD II）患者的大脑皮质功能。
Evaluation of Cerebral Cortex Function in Clients with Bipolar Mood Disorder I (BMD I) Compared With BMD II Using QEEG Analysis.
作者信息
Khaleghi Ali, Sheikhani Ali, Mohammadi Mohammad Reza, Moti Nasrabadi Ali
机构信息
Department of Biomedical Engineering, Science and Research Branch, Islamic Azad University, Tehran, Iran.
Psychiatry and Psychology Research Center, Roozbeh hospital, Tehran University of Medical Sciences, Tehran, Iran.
出版信息
Iran J Psychiatry. 2015 Apr;10(2):93-9.
OBJECTIVE
Early diagnosis of type I and type II bipolar mood disorder is very challenging particularly in adolescence. Hence, we aimed to investigate the cerebral cortex function in these patients, using quantitative electroencephalography analysis to obtain significant differences between them.
METHODS
Thirty- eight adolescents (18 patients with bipolar disorder I and 20 with BMD II) participated in this study. We recorded the electroencephalogram signals based on 10-20 international system by 21 electrodes in eyes open and eyes closed condition resting conditions. Forty seconds segments were selected from each recorded signals with minimal noise and artifacts. Periodogram Welch was used to estimate power spectrum density from each segment. Analysis was performed in five frequency bands (delta, theta, alpha, beta and gamma), and we assessed power, mean, entropy, variance and skewness of the spectrums, as well as mean of the thresholded spectrum and thresholded spectrogram. We only used focal montage for comparison. Eventually, data were analyzed by independent Mann-Whitney test and independent t test.
RESULTS
We observed significant differences in some brain regions and in all frequency bands. There were significant differences in prefrontal lobe, central lobe, left parietal lobe, occipital lobe and temporal lobe between BMD I and BMD II (P < 0.05). In patients with BMD I, spectral entropy was compared to patients with BMD II. The most significant difference was observed in the gamma frequency band. Also, the power and entropy of delta frequency band was larger in the left parietal lobe in the BMD I patients compared to BMD II patients (P < 0.05). In the temporal lobe, significant differences were observed in the spectrum distribution of beta and gamma frequency bands (P < 0.05).
CONCLUSION
The QEEG and entropy measure are simple and available tools to help detect cerebral cortex deficits and distinguish BMD I from BMD II.
目的
I型和II型双相情感障碍的早期诊断极具挑战性，尤其是在青少年中。因此，我们旨在研究这些患者的大脑皮层功能，通过定量脑电图分析来找出他们之间的显著差异。
方法
38名青少年（18名I型双相情感障碍患者和20名II型双相情感障碍患者）参与了本研究。我们根据10-20国际系统，使用21个电极在睁眼和闭眼静息状态下记录脑电图信号。从每个记录信号中选取40秒的片段，要求噪声和伪迹最小。采用周期图韦尔奇法估计每个片段的功率谱密度。在五个频段（δ、θ、α、β和γ）进行分析，我们评估了频谱的功率、均值、熵、方差和偏度，以及阈值化频谱和阈值化谱图的均值。我们仅使用焦点导联进行比较。最终，数据通过独立曼-惠特尼检验和独立t检验进行分析。
结果
我们在一些脑区和所有频段都观察到了显著差异。I型双相情感障碍和II型双相情感障碍在额叶、中央叶、左顶叶、枕叶和颞叶存在显著差异（P < 0.05）。将I型双相情感障碍患者的频谱熵与II型双相情感障碍患者进行比较。在γ频段观察到最显著的差异。此外，I型双相情感障碍患者左顶叶δ频段的功率和熵比II型双相情感障碍患者更大（P < 0.05）。在颞叶，β和γ频段的频谱分布存在显著差异（P < 0.05）。
结论
定量脑电图和熵测量是帮助检测大脑皮层缺陷并区分I型双相情感障碍和II型双相情感障碍的简单且可用的工具。
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