Moeini Mahdi, Khaleghi Ali, Amiri Nasrin, Niknam Zahra
University of Social Welfare and Rehabilitation Sciences, Razi Psychiatric Hospital, Tehran, Iran.
Psychiatry & Psychology Research Center, Tehran University of Medical Sciences, Tehran, Iran ; Department of Biomedical Engineering, Science and Research Branch, Islamic Azad University, Tehran, Iran.
Iran J Psychiatry. 2014 Oct;9(4):216-21.
The aim of this study was to achieve a better understanding of schizoaffective disorder. Therefore, we obtained electroencephalogram (EEG) signals from patients with schizoaffective disorder and analyzed them in comparison to normal subjects.
Forty patients with schizoaffective disorder and 40 normal subjects were selected randomly and their electroencephalogram signals were recorded based on 10-20 international system by 23 electrodes in open- and closed-eyes while they were sitting on a chair comfortably. After preprocessing for noise removal and artifact reduction, we took 60- second segments from each recorded signals. Then, the absolute and relative powers of these segments were evaluated in all channels and in 4 frequency bands (i.e., delta, theta, alpha and beta waves). Finally, Data were analyzed by independent t-test using SPSS software.
A significant decrease in relative power in the alpha band, a significant decrease in power spectra in the alpha band and a significant increase in power spectra in the beta band were found in patients compared to normal subjects (P < 0.05). The predominant wave in the centro-parietal region was the beta wave in patients, but it was the alpha band in normal subjects (P = 0.048). Also, the predominant wave of the occipital region in patients was the delta wave, while it was the alpha wave in normal subjects (P = 0.038).
Considering the findings, particularly based on the significant decrease of the alpha waves in schizoaffective patients, it can be concluded that schizoaffective disorder can be seen in schizophrenia spectrum.
本研究旨在更好地了解分裂情感性障碍。因此，我们获取了分裂情感性障碍患者的脑电图（EEG）信号，并与正常受试者进行比较分析。
随机选取40例分裂情感性障碍患者和40名正常受试者，让他们舒适地坐在椅子上，按照10-20国际系统，通过23个电极在睁眼和闭眼状态下记录他们的脑电图信号。在进行去噪和减少伪迹的预处理后，我们从每个记录信号中截取60秒的片段。然后，评估这些片段在所有通道和4个频段（即δ波、θ波、α波和β波）的绝对功率和相对功率。最后，使用SPSS软件通过独立样本t检验对数据进行分析。
与正常受试者相比，患者的α频段相对功率显著降低，α频段功率谱显著降低，β频段功率谱显著增加（P<0.05）。患者中央顶叶区域的优势波是β波，而正常受试者是α波（P = 0.048）。此外，患者枕叶区域的优势波是δ波，而正常受试者是α波（P = 0.038）。
考虑到研究结果，特别是基于分裂情感性障碍患者α波的显著降低，可以得出结论，分裂情感性障碍可归为精神分裂症谱系。
