再生障碍性贫血患者发生急性早幼粒细胞白血病转化：一例报告并文献复习
Acute promyelocytic leukemia transformation in a patient with aplastic anemia: a case report with literature review.
作者信息
Wang Xiaoning, Yuan Tingting, Wang Wenjuan, Chen Limei, Wang Huaiyu, Liu Yalin
机构信息
Department of Hematology, The First Affiliated Hospital of Xi'an Jiaotong University Shaan Xi, P. R. China.
Department of Clinical Laboratory, Affiliated Hospital of Yulin, Traditional Chinese Medicine of Shaan Xi Province P. R. China.
出版信息
Int J Clin Exp Med. 2015 Nov 15;8(11):20675-8. eCollection 2015.
Aplastic anemia (AA) is a hematological disorder presenting with pancytopenia in peripheral blood and hypocellularity in bone marrow. AA patients with immunosuppressive therapy and granulocyte colony-stimulating factor treatment have a risk of development of acute leukemia including acute myeloid leukemia (M0, M1, M2, M4, M5, M6) and acute lymphoblastic leukemia. However, AA with transformation to acute promyelocytic leukemia (APL) has never been reported. Here, we reported a patient initially diagnosed with AA. while 19 years later, PML/RAR αfusion gene were detected and the patient was eventually diagnosed as APL. The diagnosis and management of this interesting case are discussed.
再生障碍性贫血（AA）是一种血液系统疾病，表现为外周血全血细胞减少和骨髓细胞减少。接受免疫抑制治疗和粒细胞集落刺激因子治疗的AA患者有发生急性白血病的风险，包括急性髓系白血病（M0、M1、M2、M4、M5、M6）和急性淋巴细胞白血病。然而，从未有过AA转化为急性早幼粒细胞白血病（APL）的报道。在此，我们报告了一名最初诊断为AA的患者，19年后检测到PML/RARα融合基因，最终该患者被诊断为APL。本文讨论了这一有趣病例的诊断和处理。
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