急性早幼粒细胞白血病完全缓解后出现的严重再生障碍性贫血：这是一种偶然的关联吗？
Severe Aplastic Anemia Manifesting After Complete Remission of Acute Promyelocytic Leukemia: Is it a Fortuitous Association?
作者信息
Handigund Rajeshwari Satish, Malur Prakash R, Dhumale Annasaheb J, Bali Akshay, Roy Maitrayee, Inumella Suvarna
机构信息
Hi-Tech Laboratory, KLES Dr. Prabhakar Kore Hospital and Medical Research Centre, Belgaum, Karnataka India ; Flat 3, Ruturaj Apartments, S P Office road, Kolhapur Circle, Belgaum, Karnataka 590016 India.
Hi-Tech Laboratory, KLES Dr. Prabhakar Kore Hospital and Medical Research Centre, Belgaum, Karnataka India.
出版信息
Indian J Hematol Blood Transfus. 2014 Mar;30(1):64-7. doi: 10.1007/s12288-012-0201-8. Epub 2012 Oct 9.
Acute leukemia, secondary myelodysplasia and paroxysmal nocturnal hemoglobinuria evolving from severe aplastic anemia (AA) following immunosuppressive therapy are well recognized. However, severe AA occurring after complete remission of acute promyelocytic leukemia (APL) has been documented only once in 2009. We report a case of 30-year-old male diagnosed with APL who achieved complete cytogenetic remission with all-trans retinoic acid based induction regimen and developed severe AA few months later during maintenance therapy.
免疫抑制治疗后，由严重再生障碍性贫血（AA）演变而来的急性白血病、继发性骨髓增生异常综合征和阵发性睡眠性血红蛋白尿已得到充分认识。然而，急性早幼粒细胞白血病（APL）完全缓解后发生严重AA仅在2009年有过一次报道。我们报告一例30岁男性，诊断为APL，采用基于全反式维甲酸的诱导方案实现了细胞遗传学完全缓解，几个月后在维持治疗期间发生了严重AA。
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