Dordick J S
Department of Chemical and Materials Engineering, University of Iowa, Iowa City 52242.
Appl Biochem Biotechnol. 1989 Dec;22(3):361-73. doi: 10.1007/BF02921767.
Stereo- and regioselective biotransformations is an area of intense research interest. The ability to take advantage of microorganisms and isolated enzyme systems to perform selective organic syntheses is well known. In recent years, several new methodologies have caused a rapid growth in the area of selective biotransformations. These novel techniques include genetic and protein engineering, biocatalysis in organic media, improved screening procedures, as well as an increased awareness of the value of biotechnology to solve important problems in organic synthesis. Recent US patents and scientific literature on stereo- and regioselective biotransformations are surveyed. Patent abstracts are summarized individually and a list of literature references are given.
立体和区域选择性生物转化是一个备受关注的研究领域。利用微生物和分离的酶系统进行选择性有机合成的能力是众所周知的。近年来，几种新方法促使选择性生物转化领域迅速发展。这些新技术包括基因工程和蛋白质工程、有机介质中的生物催化、改进的筛选程序，以及人们越来越意识到生物技术在解决有机合成重要问题方面的价值。本文对近期美国关于立体和区域选择性生物转化的专利及科学文献进行了综述。专利摘要逐一进行了总结，并给出了文献参考文献列表。
