Takagi Yasushi
Department of Neurosurgery, Kyoto University Graduate School of Medicine.
Neurol Med Chir (Tokyo). 2016;56(3):110-24. doi: 10.2176/nmc.ra.2015-0340. Epub 2016 Feb 16.
"Once development was ended…in the adult centers, the nerve paths are something fixed and immutable. Everything may die, nothing may be regenerated," wrote Santiago Ramón y Cajal, a Spanish neuroanatomist and Nobel Prize winner and the father of modern neuroscience. This statement was the central dogma in neuroscience for a long time. However, in the 1960s, neural stem cells (NSCs) were discovered. Since then, our knowledge about NSCs has continued to grow. This review focuses on our current knowledge about NSCs and their surrounding microenvironment. In addition, the clinical application of NSCs for the treatment of various central nervous system diseases is also summarized.
西班牙神经解剖学家、诺贝尔奖获得者、现代神经科学之父圣地亚哥·拉蒙·伊·卡哈尔写道：“一旦发育结束……在成体中枢，神经通路是固定不变的。一切都可能死亡，没有什么可以再生。” 很长一段时间以来，这一说法一直是神经科学的核心教条。然而，在20世纪60年代，神经干细胞被发现。从那时起，我们对神经干细胞的了解不断增加。这篇综述聚焦于我们目前对神经干细胞及其周围微环境的认识。此外，还总结了神经干细胞在治疗各种中枢神经系统疾病方面的临床应用。
