1] Institute of Stem Cell Research, Helmholtz Center, Munich, Germany. [2] Biomedical Center, University of Munich, Munich, Germany.
Institute of Stem Cell Research, Helmholtz Center, Munich, Germany.
Nat Neurosci. 2015 Apr;18(4):490-2. doi: 10.1038/nn.3963. Epub 2015 Mar 2.
We analyzed the progeny of individual neural stem cells (NSCs) of the mouse adult subependymal zone (SEZ) in vivo and found a markedly fast lineage amplification, as well as limited NSC self-renewal and exhaustion in a few weeks. We further unraveled the mechanisms of neuronal subtype generation, finding that a higher proportion of NSCs were dedicated to generate deep granule cells in the olfactory bulb and that larger clones were produced by these NSCs.
我们分析了小鼠成年室下区（SEZ）中单个神经干细胞（NSC）的后代，发现其具有明显的快速谱系扩增能力，以及在数周内有限的 NSC 自我更新和耗竭。我们进一步揭示了神经元亚型生成的机制，发现更高比例的 NSCs 专门用于生成嗅球中的深颗粒细胞，并且这些 NSCs 产生了更大的克隆。
