Zhao Liang, Xu Haitao, Zhang Yubao
Department of Hepatopancreatobiliary Surgery, Harbin Medical University Cancer Hospital, Harbin, Heilongjiang 150040, P.R. China.
Exp Ther Med. 2016 Jan;11(1):348-352. doi: 10.3892/etm.2015.2875. Epub 2015 Nov 18.
The surgical management of patients with malignant biliary and duodenal obstruction is complex. Tumor excision is no longer possible in the majority of patients with malignant obstructive jaundice and duodenal obstruction. The aim of the present study was to evaluate the effectiveness of intraluminal dual stent placement in malignant biliary and duodenal obstruction. In total, 20 patients with malignant obstructive jaundice and duodenal obstruction, including 6 with pancreatic carcinoma, 11 with cholangiocarcinoma, 1 with duodenal carcinoma and 2 with abdominal lymph node metastasis, were treated with intraluminal stent placement. Bile duct obstruction with late occurrence of duodenal obstruction was observed in 16 cases, and duodenal obstruction followed by a late occurrence of bile duct obstruction was observed in 3 cases, while, in 1 case, bile duct obstruction and duodenal obstruction occurred simultaneously. After X-ray fluoroscopy revealed obstruction in the bile duct and duodenum, stents were placed into the respective lumens. Percutaneous transhepatic placement was employed for the biliary stent, while the duodenal stent was placed perioraly. The clinical outcomes, including complications associated with the procedures and patency of the stents, were evaluated. The biliary and duodenal stents were successfully implanted in 18 patients and the technical success rate was 90% (18/20). A total of 39 stents were implanted in 20 patients. In 2 cases, duodenal stent placement failed following biliary stent placement. Duodenal obstruction remitted in 15 patients, and 1 patient succumbed to aspiration pneumonia 5 days after the procedure. No severe complications were observed in any other patient. The survival time of the 18 patients was 5-21 months (median, 9.6 months), and 6 of those patients survived for >12 months. The present study suggests that X-ray fluoroscopy-guided intraluminal stent implantation is an effective procedure for the treatment of malignant biliary and duodenal obstruction.
恶性胆管和十二指肠梗阻患者的外科治疗很复杂。大多数恶性梗阻性黄疸和十二指肠梗阻患者已无法进行肿瘤切除。本研究的目的是评估腔内双支架置入术治疗恶性胆管和十二指肠梗阻的有效性。共有20例恶性梗阻性黄疸和十二指肠梗阻患者接受了腔内支架置入术治疗,其中包括6例胰腺癌患者、11例胆管癌患者、1例十二指肠癌患者和2例腹部淋巴结转移患者。观察到16例患者先出现胆管梗阻,随后出现十二指肠梗阻;3例患者先出现十二指肠梗阻,随后出现胆管梗阻;1例患者胆管梗阻和十二指肠梗阻同时发生。在X线透视显示胆管和十二指肠梗阻后,分别在相应管腔内置入支架。胆管支架采用经皮肝穿刺置入,十二指肠支架经口置入。评估了临床结局,包括与手术相关的并发症和支架通畅情况。18例患者成功植入胆管和十二指肠支架,技术成功率为90%(18/20)。20例患者共植入39枚支架。2例患者在胆管支架置入后十二指肠支架置入失败。15例患者的十二指肠梗阻缓解,1例患者在术后5天死于吸入性肺炎。其他患者均未观察到严重并发症。18例患者的生存时间为5 - 21个月(中位数为9.6个月),其中6例患者存活时间超过12个月。本研究表明,X线透视引导下的腔内支架植入术是治疗恶性胆管和十二指肠梗阻的有效方法。