Agnoletti Arianna F, DE Col Elena, Parodi Aurora, Schiavetti Irene, Savarino Vincenzo, Rebora Alfredo, Paolino Stefania, Cozzani Emanuele, Drago Francesco
Section of Dermatology, Department of Health Sciences, University of Genoa, San Martino-IST Hospital and Institute for Research and Care, Genoa, Italy -
Section of Dermatology, Department of Health Sciences, University of Genoa, San Martino-IST Hospital and Institute for Research and Care, Genoa, Italy.
G Ital Dermatol Venereol. 2017 Oct;152(5):418-423. doi: 10.23736/S0392-0488.16.05315-3. Epub 2016 Feb 18.
The aim of this study was to investigate the role of Demodex folliculorum (DF), Helicobacter pylori (HP), and small intestine bacterial overgrowth (SIBO) in the development of rosacea.
A case-control study including 60 patients with rosacea and 40 healthy controls was performed. All the patients underwent standardized skin surface biopsy to investigate DF, urea breath test for HP and lactulose breath test and glucose breath test for SIBO. Etiological therapy was started in the following order: acaricidal treatment, antibiotics for SIBO and HP. These exams were repeated after 3 years. Statistical analysis was performed.
As regards the 88 patients who completed the entire follow-up, DF positivity was found in 47.7% of the patients, SIBO in 25.0%, and HP in 21.6%. SIBO significantly prevailed in papulopustular rosacea, while HP in erythrosis. At the 6-month follow up, the 61% of patients were in remission. After 3 years, 18% of patients dropped out, while the remaining patients repeated all the investigations. The majority of patients were still in remission and negative for HP while only 5 were positive for DF and 4 for SIBO.
SIBO was the most relevant factor in papulopustular rosacea. Its treatment was crucial in improvement and in maintaining the clinical remission.
本研究旨在探讨毛囊蠕形螨(DF)、幽门螺杆菌(HP)和小肠细菌过度生长(SIBO)在酒渣鼻发病中的作用。
进行了一项病例对照研究,包括60例酒渣鼻患者和40例健康对照。所有患者均接受标准化皮肤表面活检以检测DF,进行尿素呼气试验检测HP,进行乳果糖呼气试验和葡萄糖呼气试验检测SIBO。按以下顺序开始病因治疗:杀螨治疗、针对SIBO和HP的抗生素治疗。3年后重复这些检查并进行统计分析。
在完成整个随访的88例患者中,47.7%的患者DF呈阳性,25.0%的患者SIBO呈阳性,21.6%的患者HP呈阳性。丘疹脓疱型酒渣鼻患者中SIBO明显居多,而红斑型患者中HP居多。在6个月的随访中,61%的患者病情缓解。3年后,18%的患者退出研究,其余患者重复了所有检查。大多数患者仍处于缓解状态且HP呈阴性,而只有5例患者DF呈阳性,4例患者SIBO呈阳性。
SIBO是丘疹脓疱型酒渣鼻最相关的因素。其治疗对于改善病情和维持临床缓解至关重要。