Kaur Sumandeep, Mehra Neelesh Kumar, Jain Keerti, Jain Narendra Kumar
a Pharmaceutical Nanotechnology Research Laboratory , ISF College of Pharmacy , Moga , Punjab , India.
b Department of Pharmaceutical Sciences, Pharmaceutics Research laboratory , R. H. S. Gour University , Sagar , Madhya Pradesh , India.
Artif Cells Nanomed Biotechnol. 2017 Mar;45(2):242-250. doi: 10.3109/21691401.2016.1146728. Epub 2016 Feb 18.
Our main investigation in the present research was to developt and evaluate targeting ligand-anchored multiwalled carbon nanotubes (MWCNTs) as prospective targeted drug delivery system, with a special focus on the MWCNTs surface functionalization (FA-PEG bis-amine functionalized, carboxylated MWCNTs). In vitro release of 5-fluorouracil (5-FU) was studied at pH 7.4 phosphate buffer and 5.5 acetate buffer, which displayed initial faster followed by sustained release up to 900 min. Further, 5-FU/FA-PEG bis amine-MWCNTs was found to be long circulating, prolonged half-life and increased drug accumulation in target tissue.
我们当前研究的主要调查是开发并评估靶向配体锚定的多壁碳纳米管（MWCNTs）作为潜在的靶向给药系统，特别关注MWCNTs的表面功能化（FA-PEG双胺功能化、羧基化MWCNTs）。在pH 7.4磷酸盐缓冲液和5.5醋酸盐缓冲液中研究了5-氟尿嘧啶（5-FU）的体外释放，其显示出初始较快释放，随后在长达900分钟内持续释放。此外，发现5-FU/FA-PEG双胺-MWCNTs具有长循环、延长半衰期以及增加药物在靶组织中的积累。
