Pharmacy School, Jinzhou Medical University, 40 Songpo Road, Linghe, Jinzhou, Liaoning 121001, China.
Biomed Res Int. 2018 Nov 25;2018:8526190. doi: 10.1155/2018/8526190. eCollection 2018.
In this study, we prepared PTX-loaded mesoporous hollow SnO nanofibers conjugated with folic acid (SFNFP) for liver cancer therapy. According to SEM and TEM characterization, SFNF showed a mesoporous hollow structure. The average outer diameter was 200 nm, and the wall thickness was 50 nm. The DSC and XRD study showed that PTX in the channels of nanofibers was present in an amorphous state. The in vitro release experiments demonstrated that SFNF could efficiently improve the dissolution rate of PTX. Both in vitro cell experiments and in vivo antitumor experiments showed that SFNFP could efficiently inhibit the growth of liver cancer cells. Therefore, SFNF is a promising targeting antitumor drug delivery carrier.
在这项研究中，我们制备了负载紫杉醇的介孔中空 SnO 纳米纤维与叶酸偶联（SFNFP）用于肝癌治疗。根据 SEM 和 TEM 表征，SFNF 表现出介孔中空结构。平均外径为 200nm，壁厚为 50nm。DSC 和 XRD 研究表明，纳米纤维通道中的 PTX 呈无定形态。体外释放实验表明，SFNF 可以有效提高 PTX 的溶解速率。体外细胞实验和体内抗肿瘤实验均表明，SFNFP 可以有效抑制肝癌细胞的生长。因此，SFNF 是一种有前途的靶向抗肿瘤药物载体。
