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跨越时空的基因组学政治:以巴西生物信息学为例

Genomics Politics through Space and Time: The Case of Bioinformatics in Brazil.

作者信息

Bicudo Edison

机构信息

Department of Political Economy, King's College London, London, UK.

出版信息

Public Health Genomics. 2016;19(2):81-92. doi: 10.1159/000443472. Epub 2016 Feb 19.

Abstract

The emergence of scientific disciplines, as well as the policies aimed to steer them, have geographical implications. This becomes visible in areas such as genomics and related fields. In this paper, the relation between scientific evolution, political decisions and geographical configuration is studied. The recent formation of bioinformatics in Brazil is focused on. The study involves an analysis of data collected on the website of CNPq, a funding agency attached to the Ministry of Science and Technology. Furthermore, I conducted fieldwork in four cities, interviewing 15 bioinformaticians. In the history of Brazilian bioinformatics, three periods can be identified. In the first period (1900-1996), bioinformatics was actually absent, but biology research groups were formed which would subsequently explore bioinformatics. The second period (1997-2006) was marked by the emergence of the discipline and geographical concentration of major research groups in the southern part of Brazil. A third period can be pointed to (2007-2014), in which political choices have turned geographical diffusion and institutional equality into a national target. As a consequence of the recent shifts, genomics and bioinformatics researchers have been involved in a debate, some defending the existence of few specialized research and sequencing platforms, whereas others welcoming the constitution of a scientific scenario based on decentralized platforms. I defend an intermediate solution, whereby some places would be selected to be genomics hubs. This would fit the regional diversity of this vast country, in addition to tackling the scientific weaknesses of the northern area.

摘要

科学学科的出现以及旨在引导这些学科发展的政策都具有地域影响。这在基因组学及相关领域等方面表现得很明显。本文研究了科学发展、政治决策与地理格局之间的关系。重点关注了巴西生物信息学的近期形成情况。该研究包括对隶属于科学技术部的资助机构巴西国家科学技术发展委员会(CNPq)网站上收集的数据进行分析。此外,我在四个城市进行了实地调研,采访了15位生物信息学家。在巴西生物信息学的历史中,可以识别出三个时期。在第一个时期(1900 - 1996年),生物信息学实际上并不存在,但形成了一些生物学研究小组,这些小组随后对生物信息学进行了探索。第二个时期(1997 - 2006年)的特点是该学科的出现以及主要研究小组在巴西南部的地理集中。可以指出第三个时期(2007 - 2014年),在这个时期,政治选择将地理扩散和机构平等变成了国家目标。由于近期的转变,基因组学和生物信息学研究人员参与了一场辩论,一些人捍卫少数专门研究和测序平台的存在,而另一些人则欢迎基于分散平台构建科学场景。我主张一种中间解决方案,即选择一些地方作为基因组学中心。这除了能应对北部地区的科学短板外,还将符合这个幅员辽阔国家的区域多样性。

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