Edwards J R, Matthay K K
Department of Pediatrics, University of California, San Francisco, School of Medicine.
Clin Chest Med. 1989 Dec;10(4):723-46.
Pulmonary involvement by hematologic disorders can occur through any number of mechanisms involving abnormalities of the fluid phase of hemostasis, quantitative or qualitative defects in the cellular components, and direct and indirect involvement of the malignancies derived from the hematopoietic system. Consideration of possible mechanisms through which the blood can alter pulmonary physiology and result in recognizable disorders, such as pulmonary hemorrhage, thromboembolism, fibrosis, or obstruction, can lead to more rapid and appropriate diagnosis. Further work aimed at diagnosis and management of hematologic disorders, prior to the development of pulmonary manifestations, will enable us to prevent the long-term sequelae. Intervention aimed at relieving the acute pulmonary symptoms followed by long-term management of the hematologic disease can result in significantly improved prognosis and quality of life for our patients who have manifested pulmonary symptoms secondary to a hematologic disease.
血液系统疾病累及肺部可通过多种机制发生，这些机制涉及止血液相异常、细胞成分的数量或质量缺陷，以及造血系统来源的恶性肿瘤的直接和间接累及。考虑血液可能改变肺生理并导致可识别疾病（如肺出血、血栓栓塞、纤维化或梗阻）的可能机制，有助于更快速、准确地诊断。在肺部表现出现之前，针对血液系统疾病的诊断和管理开展进一步工作，将使我们能够预防长期后遗症。针对缓解急性肺部症状并随后对血液系统疾病进行长期管理的干预措施，可显著改善继发于血液系统疾病而出现肺部症状的患者的预后和生活质量。
