中国老年男性和女性腰椎滑脱进展及新发腰椎滑脱：一项为期4年的随访研究。
Lumbar Spondylolisthesis Progression and De Novo Spondylolisthesis in Elderly Chinese Men and Women: A Year-4 Follow-up Study.
作者信息
Wáng Yì Xiáng J, Deng Min, Griffith James F, Kwok Anthony W L, Leung Jason Cs, Ahuja Anil T, Kwok Timothy, Leung Ping Chung
机构信息
Department of Imaging and Interventional Radiology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong SAR, China.
Jockey Club Centre for Osteoporosis Care and Control, School of Public Health and Primary Care, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong SAR, China.
出版信息
Spine (Phila Pa 1976). 2016 Jul 1;41(13):1096-1103. doi: 10.1097/BRS.0000000000001507.
STUDY DESIGN
Longitudinal follow-up study.
OBJECTIVE
This current study aimed to further assess progression, incidence, and risk factors of lumbar spondylolisthesis in these subjects at 4-year follow-up.
SUMMARY OF BACKGROUND DATA
A survey for osteoporotic fractures in Hong Kong during 2001 to 2003 represented the first large scale prospective population-based study on bone health in elderly (≥65 years) Chinese men and women. A follow-up study was performed at year-4.
METHODS
The lateral lumbar radiographs of 1519 male and 1546 female subjects at year-4 follow-up were analyzed using the Meyerding classification, and compared with the baseline findings.
RESULTS
Spondylolisthesis progressed in 13.0%, and de novo spondylolisthesis appeared in 12.4% in men. Spondylolisthesis progressed in 16.5%, and de novo spondylolisthesis appeared in 12.7% in women. In women, higher weight, body mass index, spine and hip bone mineral density (BMD), lower physical activity and lower grip strength were significant factors associated with spondylolisthesis progression, whereas only higher spine BMD was a marginally significant factor associated with spondylolisthesis progression for men. A weak association was noted between spondylolisthesis and lower back pain incidence in women, but not in men.
CONCLUSION
Lumbar spondylolisthesis progression in elderly Chinese at 4-year follow-up was characterized by this study.
LEVEL OF EVIDENCE
研究设计
纵向随访研究。
目的
本研究旨在对这些受试者进行4年随访，进一步评估腰椎滑脱的进展、发病率及危险因素。
背景资料总结
2001年至2003年在香港进行的一项骨质疏松性骨折调查，是针对中国老年（≥65岁）男性和女性骨骼健康的首次大规模前瞻性人群研究。在第4年进行了一项随访研究。
方法
采用迈耶丁分类法分析了1519名男性和1546名女性受试者在第4年随访时的腰椎侧位X线片，并与基线检查结果进行比较。
结果
男性中，腰椎滑脱进展者占13.0%，新发腰椎滑脱者占12.4%。女性中，腰椎滑脱进展者占16.5%，新发腰椎滑脱者占12.7%。在女性中，体重、体重指数、脊柱和髋部骨密度（BMD）较高，身体活动较少和握力较低是与腰椎滑脱进展相关的显著因素，而对于男性，只有较高的脊柱BMD是与腰椎滑脱进展相关的边缘显著因素。女性腰椎滑脱与下背痛发病率之间存在弱关联，而男性则不存在。
结论
本研究对中国老年人4年随访期间腰椎滑脱的进展情况进行了描述。
证据级别
3级。
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