老年男性无论是否存在骨质疏松性椎体骨折，其未来椎体骨折风险均明显低于老年女性：MrOS（香港）研究 4 年随访脊柱 X 线片研究。
Elderly males with or without existing osteoporotic vertebral fracture have much lower future vertebral fracture risk than elderly females: the MrOS (Hong Kong) year-4 follow-up spine radiograph study.
机构信息
Department of Imaging and Interventional Radiology, Faculty of Medicine, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong, SAR, China.
JC Centre for Osteoporosis Care and Control, Faculty of Medicine, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong, SAR, China.
出版信息
Osteoporos Int. 2019 Dec;30(12):2505-2514. doi: 10.1007/s00198-019-05136-x. Epub 2019 Sep 2.
UNLABELLED
MrOS (Hong Kong)'s year-4 follow-up shows, for subjects at baseline without vertebral deformity (VD) and endplate or/and cortex fracture (ECF), the VD progression/new VD rate during follow-up in males was half of our paired MsOS (Hong Kong) study's results. For those with VD or ECF, the VD progression/new VD was less than one sixth of females' rate.
INTRODUCTION
This study documents MrOS (Hong Kong)'s year-4 follow-up, and the results are compared with the MsOS (Hong Kong) study. Of elderly females with Genant's grade-0, -1, -2, and -3 VD, at year-4 follow-up, 4.6%, 8%, 10.6%, and 28.9% had at least one VD progression or incident VD, respectively.
METHODS
Spine radiographs of 1500 Chinese males with baseline (mean age 71.7 years, range 65-91 years) and year-4 follow-up were evaluated according to Genant's VD criteria and ECF (non-existent, ECF0; or existent, ECF1). Grade-2 VDs were divided into mild (VD2m, 25-34% height loss) and severe (VD2s, 34-40% height loss) subgroups. Study subjects were graded into eight categories: VD0/ECF0, VD1/ECF0, VD2m/ECF0, VD0/ECF1, VD1/ECF1, VD2m/ECF1, VD2s/ECF1, and VD3/ECF1. With an existing VD, a further height loss of ≥ 15% was a VD progression. A new VD incident was a change from grade-0 to grade-2/3, or to grade-1 with ≥ 10% height loss.
RESULTS
Of subjects with Genant's grade-0, 2.05% (25/1219) developed at least one VD progression or/and new VD, while of subjects with Genant's grade-1, -2, and -3 VD, only 2% (3/149), 3.1% (3/96), and 2.8% (1/36) developed at least one VD progression/new VD, respectively. Among the three ECF0 groups, there was a significant difference in new ECF incidence, with VD0/ECF0 being the lowest and VD2m/ECF0 being the highest.
CONCLUSION
VD progression/new VD is much less common in elderly men than in elderly women. Vertebrae with VD had a higher risk of developing ECF.
背景
MrOS（香港）的第 4 年随访结果显示，基线时无椎体变形（VD）和终板或/和皮质骨折（ECF）的受试者，随访期间男性的 VD 进展/新发 VD 率为我们配对的 MsOS（香港）研究结果的一半。对于有 VD 或 ECF 的患者，VD 进展/新发 VD 率不到女性的六分之一。
介绍
本研究记录了 MrOS（香港）的第 4 年随访结果，并与 MsOS（香港）研究进行了比较。在 Genant 分级为 0、1、2 和 3 的老年女性中，在第 4 年随访时，分别有 4.6%、8%、10.6%和 28.9%的患者至少出现了一次 VD 进展或新发 VD。
方法
对 1500 名基线时（平均年龄 71.7 岁，范围 65-91 岁）和第 4 年随访时的中国男性的脊柱 X 线片进行评估，根据 Genant 的 VD 标准和 ECF（不存在，ECF0；或存在，ECF1）进行评估。2 级 VD 分为轻度（VD2m，25-34%的高度损失）和重度（VD2s，34-40%的高度损失）亚组。研究对象分为八类：VD0/ECF0、VD1/ECF0、VD2m/ECF0、VD0/ECF1、VD1/ECF1、VD2m/ECF1、VD2s/ECF1 和 VD3/ECF1。对于存在 VD 的患者，进一步的高度损失≥15%为 VD 进展。新发 VD 为从 0 级变为 2/3 级或从 1 级变为≥10%高度损失。
结果
在 Genant 分级为 0 级的患者中，有 2.05%（25/1219）至少出现了一次 VD 进展或新发 VD，而在 Genant 分级为 1、2 和 3 级的患者中，只有 2%（3/149）、3.1%（3/96）和 2.8%（1/36）至少出现了一次 VD 进展/新发 VD。在三个 ECF0 组中，新发 ECF 发生率存在显著差异，VD0/ECF0 最低，VD2m/ECF0 最高。
结论
与老年女性相比，老年男性的 VD 进展/新发 VD 发生率要低得多。有 VD 的椎骨发生 ECF 的风险更高。
Zotero 插件