Pena Geórgia G, Martinez-Perez Angel, Dutra Míriam Santos, Gazzinelli Andrea, Corrêa-Oliveira Rodrigo, Soria José M, Velasquez-Melendez Gustavo
School of Medicine, Universidade Federal de Uberlândia 1720, Pará Av., Umuarama, Uberlândia, Minas Gerais, 38400-902, Brazil.
Department of Maternal and Child Nursing and Public Health, School of Nursing, Universidade Federal de Minas Gerais. 190, Alfredo Balena Av., Santa Efigênia, Belo Horizonte, Minas Gerais, 30130-100, Brazil.
Am J Hum Biol. 2016 Sep 10;28(5):619-26. doi: 10.1002/ajhb.22842. Epub 2016 Feb 19.
The purpose of this study was to estimate the heritability of genetic and environmental correlations between cardiometabolic risk factors in extended pedigrees.
The Jequitinhonha Community Family Study Cohort (JCFSC) consists of individuals aged ≥18 years living in rural villages. Family pedigrees were constructed of the cohort. The following data were collected: demographic and socioeconomic status, lifestyle variables, anthropometrics, and lipid traits.
The JCFSC consists of 931 individuals distributed into 69 pedigrees with 4,907 members in total. The heritabilities were 0.47 for total cholesterol (TC), 0.44 for triglycerides (TG) and 0.42 for high-density lipoprotein cholesterol (HDLc), 0.49 for metabolic syndrome, approximately 0.60 for anthropometric traits and 0.30 for blood pressure/hypertension. Significant genetic correlations (ρg ) were found mainly between TG and TC (ρg = 0.58) and hypertension and TG (ρg = 0.52). Systolic blood pressure (SBP) was correlated with TG (ρg = 0.39) and HDLc (ρg = -0.30). Diastolic blood pressures correlated with TG (ρg =0.56) and TC (ρg =0.30). Genetic correlations were also found between anthropometric traits, including: body mass index (BMI) and TG (ρg =0.34), waist circumference (WC) and TG (ρg =0.42), and WC and HDLc (ρg =-0.33). Household effects were found for HDLc (c(2) = 0.19), SBP (c(2) = 0.14) and Hypertension (c(2) = 0.14).
To some phenotypes, including lipids, hypertension, blood pressure, and anthropometric traits, genetic contribution is important in the determination of cardiometabolic risk factors. This study provides a foundation for future studies. These will mainly focus on rare variants that could describe the genetic mechanisms influencing cardiometabolic risk. Am. J. Hum. Biol. 28:619-626, 2016. © 2016 Wiley Periodicals, Inc.
本研究旨在评估扩展家系中心血管代谢危险因素之间遗传和环境相关性的遗传度。
热基蒂纽翁哈社区家庭研究队列（JCFSC）由居住在乡村的18岁及以上个体组成。构建了该队列的家系图谱。收集了以下数据：人口统计学和社会经济状况、生活方式变量、人体测量学数据和血脂特征。
JCFSC由931名个体组成，分布在69个家系中，共计4907名成员。总胆固醇（TC）的遗传度为0.47，甘油三酯（TG）为0.44，高密度脂蛋白胆固醇（HDLc）为0.42，代谢综合征为0.49，人体测量学特征约为0.60，血压/高血压为0.30。主要在TG与TC（ρg = 0.58）以及高血压与TG（ρg = 0.52）之间发现了显著的遗传相关性。收缩压（SBP）与TG（ρg = 0.39）和HDLc（ρg = -0.30）相关。舒张压与TG（ρg = 0.56）和TC（ρg = 0.30）相关。在人体测量学特征之间也发现了遗传相关性，包括：体重指数（BMI）与TG（ρg = 0.34）、腰围（WC）与TG（ρg = 0.42）以及WC与HDLc（ρg = -0.33）。发现HDLc（c(2) = 0.19）、SBP（c(2) = 0.14）和高血压（c(2) = 0.14）存在家庭效应。
对于某些表型，包括血脂、高血压、血压和人体测量学特征，遗传因素在心血管代谢危险因素的决定中很重要。本研究为未来的研究奠定了基础。这些研究将主要关注可能描述影响心血管代谢风险的遗传机制的罕见变异。《美国人类生物学杂志》28:619 - 626，2016年。© 2016威利期刊公司
