Pena Geórgia G, Dutra Míriam Santos, Gazzinelli Andrea, Corrêa-Oliveira Rodrigo, Velasquez-Melendez Gustavo
Departamento de Enfermagem Materno-Infantil e Saúde Pública, Escola de Enfermagem, Universidade Federal de Minas Gerais, Escola de Enfermagem, Avenida Alfredo Balena 190, Belo Horizonte, MG, 30130-100, Brazil.
Ann Hum Genet. 2014 Jan;78(1):40-9. doi: 10.1111/ahg.12047.
We aimed to estimate the heritability and genetic correlation between glucose homeostasis and adiposity traits in a population in a rural community in Brazil. The Jequitinhonha Community Family Study cohort consists of subjects aged ≥18 years residing in rural areas in Brazil. The data on the following traits were assembled for 280 individuals (51.7% women): body mass index (BMI), body fat percentage, waist and mid-upper arm circumferences, triceps skinfold, conicity index, insulin, glucose, high-density lipoprotein cholesterol (HDLc), triglycerides and C-reactive protein. Extended pedigrees were constructed up to the third generation of individuals using the data management software PEDSYS. The heritability and genetic correlations were estimated using a variance component method. The age- and sex-adjusted heritability values estimated for insulin (h(2) = 52%), glucose (h(2) = 51%), HDLc (h(2) = 58%), and waist circumference (WC; h(2) = 49%) were high. Significantly adjusted genetic correlations were observed between insulin paired with each of the following phenotypes; (BMI; ρg = 0.48), WC (ρg = 0.47) and HDLc (ρg = -0.47). The homeostasis model assessment of insulin resistance (HOMA-IR) was genetically correlated with BMI (ρg = 0.53) and HDLc (ρg = -0.58). The adjusted genetic correlations between traits were consistently higher compared with the environmental correlations. In conclusion, glucose metabolism and adiposity traits are highly heritable and share common genetic effects with body adiposity traits.
我们旨在估计巴西一个农村社区人群中葡萄糖稳态与肥胖特征之间的遗传力和遗传相关性。热基蒂尼奥尼亚社区家庭研究队列由居住在巴西农村地区、年龄≥18岁的受试者组成。收集了280名个体（51.7%为女性）以下特征的数据：体重指数（BMI）、体脂百分比、腰围和上臂中部周长、肱三头肌皮褶厚度、锥度指数、胰岛素、葡萄糖、高密度脂蛋白胆固醇（HDLc）、甘油三酯和C反应蛋白。使用数据管理软件PEDSYS构建了直至第三代个体的扩展家系。采用方差成分法估计遗传力和遗传相关性。胰岛素（h(2)=52%）、葡萄糖（h(2)=51%）、HDLc（h(2)=58%）和腰围（WC；h(2)=49%）的年龄和性别调整遗传力值较高。观察到胰岛素与以下每种表型之间存在显著调整的遗传相关性：（BMI；ρg = 0.48）、WC（ρg = 0.47）和HDLc（ρg = -0.47）。胰岛素抵抗的稳态模型评估（HOMA-IR）与BMI（ρg = 0.53）和HDLc（ρg = -0.58）存在遗传相关性。与环境相关性相比，性状之间的调整遗传相关性始终更高。总之，葡萄糖代谢和肥胖特征具有高度遗传性，并且与身体肥胖特征共享共同的遗传效应。
