[中枢单胺能神经元在调节自愿乙醇摄入中的作用]
[The role of central monoamine neurons in regulating voluntary ethanol consumption].
作者信息
Kiiianmaa K
出版信息
Farmakol Toksikol. 1989 Sep-Oct;52(5):4-10.
One approach used in this laboratory for determining the neurophysiological basis for ethanol intake has been to manipulate the function of brain monoamine systems. Lesion studies and work with REM-sleep deprived rats suggested a role for brain noradrenaline neurons in ethanol intake. Another approach has been to study the relationship between different monoamine transmitters and ethanol intake in AA and ANA rat strains. The observed monoaminergic differences do not seem to explain the difference in ethanol intake between the strains. The two different approaches thus do not provide a single, simple hypothesis for how ethanol consumption is controlled.
本实验室用于确定乙醇摄入神经生理基础的一种方法是操纵脑单胺系统的功能。损伤研究以及对快速眼动睡眠剥夺大鼠的研究表明，脑去甲肾上腺素能神经元在乙醇摄入中起作用。另一种方法是研究不同单胺递质与AA和ANA大鼠品系中乙醇摄入之间的关系。观察到的单胺能差异似乎无法解释品系间乙醇摄入量的差异。因此，这两种不同的方法并未为乙醇消耗的控制提供一个单一、简单的假说。
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