胰岛淀粉样多肽对葡萄糖的分泌反应。
Secretion of islet amyloid polypeptide in response to glucose.
作者信息
Kanatsuka A, Makino H, Ohsawa H, Tokuyama Y, Yamaguchi T, Yoshida S, Adachi M
机构信息
Second Department of Internal Medicine, Chiba University School of Medicine, Japan.
出版信息
FEBS Lett. 1989 Dec 18;259(1):199-201. doi: 10.1016/0014-5793(89)81527-3.
The content of islet amyloid polypeptide (IAPP) in isolated rat pancreatic islets was determined by a radioimmunoassay. Reverse-phase high-performance liquid chromatography analysis revealed that a main peak of IAPP immunoreactivity in the extracts from the islets corresponded to a synthetic rat IAPP. Secretion of IAPP from the cells is regulated by the extracellular glucose concentration. Thus, IAPP may be a novel regulator for glucose homeostasis and changes in the secretion perhaps relate to insular amyloid deposits and impaired glucose tolerance in type 2 diabetes mellitus.
采用放射免疫分析法测定了分离的大鼠胰岛中胰岛淀粉样多肽（IAPP）的含量。反相高效液相色谱分析显示，胰岛提取物中IAPP免疫反应性的一个主峰与合成的大鼠IAPP相对应。细胞分泌IAPP受细胞外葡萄糖浓度调节。因此，IAPP可能是葡萄糖稳态的一种新型调节因子，其分泌变化可能与2型糖尿病中的胰岛淀粉样沉积和葡萄糖耐量受损有关。
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