Lam Jonathan, Chan Geoffrey, Morgan William H, Hazelton Martin, Betz-Stablein Brigid, Cringle Stephen J, Yu Dao Yi
Lions Eye Institute, The University of Western Australia, Perth, Australia.
Lions Eye Institute, The University of Western Australia, Perth, Australia; Centre for Ophthalmology and Visual Science, The University of Western Australia, Perth, Australia.
Exp Eye Res. 2016 Apr;145:341-346. doi: 10.1016/j.exer.2016.02.003. Epub 2016 Feb 15.
The relationship between structural characteristics of the optic nerve head and venous pulsations in the human eye remain unknown. Using photoplethysmographic techniques we investigated whether properties of the human retinal veins and their surrounding structures influence venous pulsation. 448 locations of venous pulsation were analysed from 26 normal human eyes. Green channel densitometry derived from video recordings of venous pulsations were used to generate a map of venous pulsation amplitudes along retinal veins. Optical coherence tomography was used to perform quantitative measurements of tissue characteristics at sites of high and low amplitude points as well as in a second analysis, at maximal amplitude pulsation sites from superior and inferior halves of the eyes. Structural characteristics measured included venous diameter, distance from pulsation point to cup margin, vessel length from pulsation point to vein exit, tissue thickness overlying vein, optic disc diameter and presence of a proximal arteriovenous crossing. Increasing venous pulsation amplitudes were associated with larger applied ophthalmodynamometry force, increasing venous diameter, and decreasing absolute cup margin distance (all p < 0.001). Increasing distance of maximal amplitude pulsation point to cup margin was associated with the presence of a proximal arteriovenous crossing, increasing venous diameter, and decreasing tissue depth (all p ≤ 0.001). Venous diameter and tissue depth alter venous compliance, which is likely to be a major factor determining sites of venous pulsation.
人眼视神经乳头的结构特征与静脉搏动之间的关系尚不清楚。我们使用光电容积描记技术研究了人视网膜静脉及其周围结构的特性是否会影响静脉搏动。对26只正常眼睛的448个静脉搏动位置进行了分析。利用静脉搏动视频记录得出的绿色通道密度测定法生成了沿视网膜静脉的静脉搏动幅度图。光学相干断层扫描用于对高、低幅度点以及在第二次分析中对眼睛上、下半部最大幅度搏动点处的组织特征进行定量测量。测量的结构特征包括静脉直径、搏动点到视杯边缘的距离、从搏动点到静脉出口的血管长度、静脉上方的组织厚度、视盘直径以及近端动静脉交叉的存在情况。静脉搏动幅度增加与更大的眼动脉压测量力、静脉直径增加和绝对视杯边缘距离减小相关（所有p<0.001）。最大幅度搏动点到视杯边缘的距离增加与近端动静脉交叉的存在、静脉直径增加和组织深度减小相关（所有p≤0.001）。静脉直径和组织深度改变静脉顺应性，这可能是决定静脉搏动部位的主要因素。
