中国河北省发现的9种新型HIV-1重组毒株的重组模式
Recombinant Patterns of Nine Novel HIV-1 Recombinant Strains Identified in Hebei Province, China.
作者信息
Lu Xinli, Liu Yongjian, Zhao Hongru, Zhang Yuqi, Zhao Cuiying, Chen Suliang, Li Jingyun, Cui Ze
机构信息
1 Hebei Provincial Center for Disease Control and Prevention , Shjiazhuang, People's Republic of China .
2 Department of AIDS Research, State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology , Beijing, People's Republic of China .
出版信息
AIDS Res Hum Retroviruses. 2016 May;32(5):475-9. doi: 10.1089/AID.2016.0005. Epub 2016 Mar 23.
We found cluster 1 and cluster 2 that were identified as two potential circulating recombinant forms (CRFs) by analyzing the recombinant breakpoints and phylogenetic tree. Three sequences composed of CRF01_AE, subtype C, and potential subtype B (N/A) in cluster 1 had nearly identical recombinant breakpoints, and four sequences composed of CRF01_AE and subtype B in cluster 2 possessed identical breakpoints. Demographic characteristics indicated that there were no epidemiological linkages among three subjects in cluster 1 and four subjects in cluster 2, respectively. Likewise, two unique recombinant forms (URFs) were found in this study: one URF was composed of subtype C and subtype B, and subtype B was inserted into a backbone of subtype C; another URF was composed of subtype C, subtype B, CRF01_AE, and subtype A2. It was inferred that the potential novel CRFs and URFs have spread into general populations, suggesting that the series research of novel recombinant strains will be a priority for our researches in the future.
通过分析重组断点和系统发育树，我们发现了簇1和簇2，它们被鉴定为两种潜在的循环重组形式（CRF）。簇1中由CRF01_AE、C亚型和潜在的B亚型（未明确）组成的三个序列具有几乎相同的重组断点，簇2中由CRF01_AE和B亚型组成的四个序列具有相同的断点。人口统计学特征表明，簇1中的三名受试者和簇2中的四名受试者之间分别没有流行病学联系。同样，本研究中发现了两种独特的重组形式（URF）：一种URF由C亚型和B亚型组成，B亚型插入到C亚型的主干中；另一种URF由C亚型、B亚型、CRF01_AE和A2亚型组成。据推测，潜在的新型CRF和URF已传播到普通人群中，这表明新型重组菌株的系列研究将是我们未来研究的重点。
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