Grodin Erica N, Steckler Leah E, Momenan Reza
Clinical NeuroImaging Research Core, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD, USA Brown-National Institutes of Health Graduate Partnership Program, Bethesda, MD, USA.
Clinical NeuroImaging Research Core, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD, USA.
Alcohol Alcohol. 2016 Nov;51(6):638-646. doi: 10.1093/alcalc/agw003. Epub 2016 Feb 17.
To use functional magnetic resonance imaging (fMRI) to investigate the neural circuitry behind effort-related valuation and motivation in a population of alcohol-dependent participants and healthy controls.
Seventeen alcohol-dependent participants and a comparison group of 17 healthy control participants completed an effort-based motivation paradigm during an fMRI scan, in which they were required to exert effort at varying levels in order to earn a monetary reward.
We found that alcohol-dependent participants were less motivated during trials requiring high levels of effort. The whole-brain fMRI analysis revealed that alcohol-dependent participants displayed an increased blood-oxygen-level dependent (BOLD) signal during low and unknown effort cues in the dorsal and ventral striatum compared with healthy controls.
These findings provide the first evidence that alcohol-dependent participants and healthy controls differ in their effort-based valuation and motivation processing. Alcohol-dependent participants displayed a hyperactive mesolimbic reward circuitry recruited by non-drug rewards, potentially reflecting a sensitization to reward in this patient population.
运用功能磁共振成像（fMRI）研究酒精依赖参与者和健康对照人群中与努力相关的评估和动机背后的神经回路。
17名酒精依赖参与者和17名健康对照参与者组成的比较组在fMRI扫描期间完成了基于努力的动机范式，在此过程中，他们需要付出不同程度的努力以获得金钱奖励。
我们发现，在需要高水平努力的试验中，酒精依赖参与者的积极性较低。全脑fMRI分析显示，与健康对照相比，酒精依赖参与者在背侧和腹侧纹状体的低努力和未知努力线索期间，血氧水平依赖（BOLD）信号增强。
这些发现首次证明，酒精依赖参与者和健康对照在基于努力的评估和动机处理方面存在差异。酒精依赖参与者表现出由非药物奖励招募的中脑边缘奖赏回路过度活跃，这可能反映了该患者群体对奖励的敏感化。
