Fazekas J T, Scott C, Marcial V, Davis L W, Wasserman T, Cooper J S
Division of Radiation Oncology, Rutland Regional Medical Center, VT 05701.
Int J Radiat Oncol Biol Phys. 1989 Dec;17(6):1177-81. doi: 10.1016/0360-3016(89)90523-3.
Recent data from the DAHANCA (Danish Head and Neck Cancer) 2 study implies a positive effect of high hemoglobin concentration in concert with misonidazole for the treatment of head and neck cancers by radiotherapy. We have therefore reviewed and updated our analysis of RTOG protocol 79-15, which included the effect of misonidazole plus radiotherapy in a presumably similar population. Despite additional follow-up and more sophisticated analysis, our analysis does not demonstrate an influence of hemoglobin concentration on any of the outcome measures we examined. Possible explanations for the difference in findings of RTOG 79-15 and DAHANCA 2 are discussed. Radiation therapy of head and neck squamous cancers, Hypoxia and hemoglobin conc. in head and neck cancers, Oral cavity cancer, Effect of radiation therapy, Oropharynx cancer, Hemoglobin and radiotherapy, Hemoglobin concentration, Effect upon radiotherapy, Irradiation of oropharynx cancer, Hgb effect.
DAHANCA（丹麦头颈癌）2研究的最新数据表明，高血红蛋白浓度与米索硝唑联合使用对通过放射治疗头颈癌具有积极作用。因此，我们回顾并更新了对RTOG协议79 - 15的分析，该协议包括米索硝唑加放射治疗在可能相似人群中的效果。尽管进行了额外的随访和更复杂的分析，但我们的分析并未证明血红蛋白浓度对我们所检查的任何结果指标有影响。文中讨论了RTOG 79 - 15和DAHANCA 2研究结果差异的可能解释。头颈鳞状癌的放射治疗、头颈癌中的缺氧和血红蛋白浓度、口腔癌、放射治疗的效果、口咽癌、血红蛋白与放射治疗、血红蛋白浓度、对放射治疗的影响、口咽癌的照射、血红蛋白的作用
