Asanuma Katsuhiko, Oliva Trejo Juan Alejandro, Tanaka Eriko
Medical Innovation Center, TMK Project, Graduate School of Medicine, Kyoto University, 53 Shogoin Kawahara-cho, Sakyo-ku, Kyoto, 606-8507, Japan.
Division of Nephrology, Department of Internal Medicine, Faculty of Medicine, Juntendo University, Tokyo, Japan.
Clin Exp Nephrol. 2017 Feb;21(1):1-6. doi: 10.1007/s10157-016-1247-y. Epub 2016 Feb 19.
The Notch signaling pathway is a basic cell-to-cell communication mechanism. This pathway is activated by the interaction between Notch receptors and the ligands of adjacent cells. Once activated, Notch receptors are cleaved and the intracellular domains translocate into the nucleus, where the transcription of target genes starts. In the mammalian kidney, Notch receptors are activated during nephrogenesis. Afterwards, in the mature glomeruli, the Notch pathway becomes silent. However, many researchers have reported the activation of Notch receptors in mature podocytes under pathological conditions. In this review, we discuss the role of Notch signaling in podocytes.
Notch信号通路是一种基本的细胞间通讯机制。该通路通过Notch受体与相邻细胞配体之间的相互作用而被激活。一旦被激活，Notch受体就会被切割，其细胞内结构域转移到细胞核中，在那里启动靶基因的转录。在哺乳动物肾脏中，Notch受体在肾发生过程中被激活。之后，在成熟的肾小球中，Notch通路变得沉默。然而，许多研究人员报道了在病理条件下成熟足细胞中Notch受体的激活。在本综述中，我们讨论了Notch信号在足细胞中的作用。
