Hundozi Zylfije, Shala Argjend, Boshnjaku Dren, Bytyqi Samir, Rrustemi Jehona, Rama Muhamed, Jashari Fisnik
Department of Neurology, University Clinical Center of Kosovo, Pristina, Kosovo; Department of Neurology, University of Pristina, Pristina, Kosovo.
Department of Neurology, University Clinical Center of Kosovo, Pristina, Kosovo.
Seizure. 2016 Mar;36:40-43. doi: 10.1016/j.seizure.2016.01.016. Epub 2016 Feb 4.
Despite the common occurrence of early seizures (ES) after stroke, the relationship between risk factors and this complication of stroke is not well established. In this study we have examined the relationship between clinical measures on admission and ES after stroke.
We included 1073 patients (mean age 69 ± 12, 51.6% females) with ischemic and haemorrhagic stroke. The frequency of seizure occurrence within 2 weeks of stroke was determined. We used a logistic regression model to analyse the effect of blood pressure on admission and other clinical factors (age, gender, diabetes, atrial fibrillation and dyslipidemia) on the occurrence of ES after stroke.
ES occurred after 4.1% and 4.0% of ischemic and haemorrhagic strokes respectively. Compared to patients with high blood pressure on admission, those with low and normal blood pressure had a higher risk of ES after stroke (2.9% vs.7.5% vs. 7.6%, p=0.001). Also the mean age of patients with post-stroke ES was lower (62.5 vs. 69.3, p<0.001). In a logistic regression analysis, low/normal blood pressure remained independently associated with ES after stroke with OR of 2.46 (95% CI 1.38-4.63, p=0.006).
ES after stroke was equally frequent in patients with ischemic and haemorrhagic stroke. Low/normal blood pressure on admission and younger patient age were risk factors for ES after stroke.
尽管卒中后早期癫痫发作（ES）很常见，但风险因素与这种卒中并发症之间的关系尚未完全明确。在本研究中，我们探讨了入院时的临床指标与卒中后ES之间的关系。
我们纳入了1073例缺血性和出血性卒中患者（平均年龄69±12岁，女性占51.6%）。确定卒中后2周内癫痫发作的频率。我们使用逻辑回归模型分析入院时血压及其他临床因素（年龄、性别、糖尿病、心房颤动和血脂异常）对卒中后ES发生的影响。
缺血性和出血性卒中后ES的发生率分别为4.1%和4.0%。与入院时血压高的患者相比，血压低和正常的患者卒中后发生ES的风险更高（2.9%对7.5%对7.6%，p=0.001）。卒中后发生ES的患者平均年龄也更低（62.5对69.3，p<0.001）。在逻辑回归分析中，血压低/正常仍然与卒中后ES独立相关，比值比为2.46（95%置信区间1.38 - 4.63，p=0.006）。
缺血性和出血性卒中患者卒中后ES的发生率相当。入院时血压低/正常以及患者年龄较轻是卒中后ES的风险因素。
