Grover Shilpa, Jajoo Kunal
Division of Gastroenterology, Brigham and Women's Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA.
Division of Gastroenterology, Brigham and Women's Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA.
Gastroenterol Clin North Am. 2016 Mar;45(1):117-27. doi: 10.1016/j.gtc.2015.10.001. Epub 2016 Jan 12.
Pancreatic adenocarcinoma is a leading cause of cancer death. Few patients are candidates for curative resection due to the late stage at diagnosis. While most pancreatic adenocarcinomas are sporadic, approximately 10% have an underlying hereditary basis. Known genetic syndromes account for only 20% of the familial clustering of pancreatic cancer cases. The majority are due to non-syndromic aggregation of pancreatic cancer cases or familial pancreatic cancer. Screening aims to identify high-risk lesions amenable to surgical resection. However, the optimal interval for screening and the management of pancreatic cancer precursor lesions detected on imaging are controversial.
胰腺腺癌是癌症死亡的主要原因。由于诊断时处于晚期，很少有患者适合进行根治性切除。虽然大多数胰腺腺癌是散发性的，但约10%有潜在的遗传基础。已知的遗传综合征仅占胰腺癌病例家族聚集性的20%。大多数是由于胰腺癌病例的非综合征性聚集或家族性胰腺癌。筛查旨在识别适合手术切除的高危病变。然而，筛查的最佳间隔以及对影像学检查发现的胰腺癌前驱病变的管理仍存在争议。
