Khan Aqsa, Mushtaq Rizwan, Rashad Essam, Mushtaq Kamran, Sharma Neil
Internal Medicine, Parkview Health, Fort Wayne, USA.
Internal Medicine, Ayub Medical College, Abbottabad, PAK.
Cureus. 2025 Feb 13;17(2):e78955. doi: 10.7759/cureus.78955. eCollection 2025 Feb.
Autoimmune pancreatitis (AIP) is an uncommon inflammatory condition that can mimic pancreatic malignancy both clinically and radiologically, leading to diagnostic uncertainty. Two subtypes exist: Type 1 is linked to systemic IgG4-related disease, and Type 2 is confined to the pancreas. A 64-year-old woman was found to have submandibular and cervical lymphadenopathy during a routine physical examination. Further imaging revealed FDG-avid lymph nodes and pancreatic abnormalities, raising concern for malignancy. However, biopsy results confirmed Type 1 autoimmune pancreatitis (AIP) and IgG4-related sialadenitis. The patient was treated with corticosteroids, which resolved her symptoms and improved imaging findings. This case emphasizes the need to consider atypical presentations of AIP and highlights the effectiveness of steroid therapy in IgG4-related diseases.
自身免疫性胰腺炎（AIP）是一种罕见的炎症性疾病，在临床和影像学上都可能酷似胰腺恶性肿瘤，导致诊断存在不确定性。它有两种亚型：1型与全身性IgG4相关疾病有关，2型则局限于胰腺。一名64岁女性在常规体检中被发现有颌下和颈部淋巴结病。进一步的影像学检查显示有氟脱氧葡萄糖（FDG）摄取增加的淋巴结及胰腺异常，引发了对恶性肿瘤的担忧。然而，活检结果证实为1型自身免疫性胰腺炎（AIP）和IgG4相关涎腺炎。患者接受了皮质类固醇治疗，症状得以缓解，影像学表现也有所改善。该病例强调了需要考虑AIP的非典型表现，并突出了类固醇疗法在IgG4相关疾病中的有效性。
