Yu Yuan, Fan Yaofu, Yang Zongguo, Lu Yunfei, Xu Qingnian, Chen Xiaorong
Department of Traditional Chinese Medicine, Shanghai Public Health Clinical Center, Fudan University, Shanghai 201508, China.
Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing, Jiangsu 210023, China.
Discov Med. 2016 Jan;21(113):7-14.
Recently, several studies have demonstrated that serum gamma-glutamyltransferase (GGT) is associated with some diseases, such as chronic hepatitis B (CHB). This study investigates the association between GGT levels and liver pathological grading in patients with CHB. 300 patients with CHB who underwent liver biopsy were enrolled. Histological assessment was based on the Scheuer scoring system. Univariate and multivariate analyses were performed to evaluate the independent predicting factors for the presence of liver pathological grade in patients with CHB. In patients with CHB, the mean GGT level was 44.14±3.69 (U/L) in low activity group and 114.87±15.75 (U/L) in the high activity group (p<0.001). Also, there was significant difference between the low and high fibrosis group with regard to GGT levels [45.32±4.64 (U/L) vs. 90.41±11.06 (U/L), p<0.001, respectively]. The variables that were significant in the univariate analysis were evaluated in multivariate logistic regression analysis, and GGT was an independent predicting factor of necroinflammation and fibrosis (OR=1.007, 95%CI: 1.001-1.014, p=0.030; OR=1.009, 95%CI: 1.003-1.014, p=0.003, respectively). Results of this study suggest that GGT is a new non-invasive marker that can be used to predict advanced histological liver damage.
最近，多项研究表明血清γ-谷氨酰转移酶（GGT）与某些疾病相关，如慢性乙型肝炎（CHB）。本研究调查CHB患者GGT水平与肝脏病理分级之间的关联。纳入300例行肝活检的CHB患者。组织学评估基于Scheuer评分系统。进行单因素和多因素分析以评估CHB患者肝脏病理分级存在的独立预测因素。CHB患者中，低活动组的平均GGT水平为44.14±3.69（U/L），高活动组为114.87±15.75（U/L）（p<0.001）。此外，低纤维化组和高纤维化组之间的GGT水平也存在显著差异[分别为45.32±4.64（U/L）和90.41±11.06（U/L），p<0.001]。在单因素分析中有显著意义的变量在多因素逻辑回归分析中进行评估，GGT是坏死性炎症和纤维化的独立预测因素（OR=1.007，95%CI：1.001-1.014，p=0.030；OR=1.009，95%CI：1.003-1.014，p=0.003）。本研究结果表明，GGT是一种可用于预测肝脏组织学高级别损伤的新型非侵入性标志物。
