头颈部肿瘤中肿瘤抑制基因治疗的潜力。
The potential for tumor suppressor gene therapy in head and neck cancer.
作者信息
Birkeland Andrew C, Ludwig Megan L, Spector Matthew E, Brenner J Chad
机构信息
Department of Otolaryngology - Head and Neck Surgery, University of Michigan Health System, Ann Arbor, MI 48109, USA.
出版信息
Discov Med. 2016 Jan;21(113):41-7.
Head and neck squamous cell carcinoma remains a highly morbid and fatal disease. Importantly, genomic sequencing of head and neck cancers has identified frequent mutations in tumor suppressor genes. While targeted therapeutics increasingly are being investigated in head and neck cancer, the majority of these agents are against overactive/overexpressed oncogenes. Therapy to restore lost tumor suppressor gene function remains a key and under-addressed niche in trials for head and neck cancer. Recent advances in gene editing have captured the interest of both the scientific community and the public. As our technology for gene editing and gene expression modulation improves, addressing lost tumor suppressor gene function in head and neck cancers is becoming a reality. This review will summarize new techniques, challenges to implementation, future directions, and ethical ramifications of gene therapy in head and neck cancer.
头颈部鳞状细胞癌仍然是一种高发病率和致命性的疾病。重要的是，头颈部癌症的基因组测序已确定肿瘤抑制基因中存在频繁突变。虽然针对头颈部癌症的靶向治疗越来越受到研究，但这些药物大多针对过度活跃/过度表达的癌基因。恢复缺失的肿瘤抑制基因功能的治疗在头颈部癌症试验中仍然是一个关键且未得到充分解决的领域。基因编辑的最新进展引起了科学界和公众的关注。随着我们用于基因编辑和基因表达调控的技术不断改进，解决头颈部癌症中缺失的肿瘤抑制基因功能正成为现实。本综述将总结头颈部癌症基因治疗的新技术、实施挑战、未来方向和伦理影响。
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