氙气与其他吸入性麻醉剂恢复参数的比较：系统评价与荟萃分析

Comparison of recovery parameters for xenon versus other inhalation anesthetics: systematic review and meta-analysis.

作者信息

Hou Bingzong, Li Fujing, Ou Shanshan, Yang Lukun, Zhou Shaopeng

机构信息

Department of General Surgery, Fifth Affiliated Hospital of Sun Yat-Sen University, No. 52 East Meihua Road, Zhuhai, Guangdong 519000, China.

Department of Anaesthesiology, Fifth Affiliated Hospital of Sun Yat-Sen University, No. 52 East Meihua Road, Zhuhai, Guangdong 519000, China.

出版信息

J Clin Anesth. 2016 Mar;29:65-74. doi: 10.1016/j.jclinane.2015.10.018. Epub 2016 Feb 3.

DOI:10.1016/j.jclinane.2015.10.018

PMID:26897451

Abstract

STUDY OBJECTIVE

To summarize and evaluate the available data describing the recovery parameters of xenon anesthesia.

DESIGN

Systematic review and meta-analysis.

SETTING

Anesthesia for elective surgeries.

PATIENTS

Systematic review of randomized controlled trials (RCTs) from databases including Medline (1964-2013), the Cochrane Central Register of Controlled Trials (CENTRAL, 1990-2012), and Google Scholar (1966-2013).

INTERVENTIONS

Inhalation of xenon or other anesthetics was administered in elective surgery.

MEASUREMENTS

Recovery parameters (time to recovery, alertness/sedation scale scores at "eye opening," bispectral index at "reaction on demand," time to extubation, and time to orientation).

MAIN RESULTS

Eleven RCTs (N = 661 patients) met the inclusion criteria. Recovery from xenon anesthesia was significantly faster in terms of the time to eye opening (mean difference [MD], -4.18 minutes; 95% confidence interval [CI], -5.03 to -3.32 minutes; P < .00001), the time to reaction on demand (MD, -5.35 minutes; 95% CI, -6.59 to -4.11 minutes; P < .00001), the time to extubation (MD, -4.49 minutes; 95% CI, -5.40 to -3.58 minutes; P < .00001), and the time to orientation (MD, -4.99 minutes; 95% CI, -6.45 to -3.52 minutes; P < .00001).

CONCLUSIONS

This meta-analysis confirmed that recovery from xenon anesthesia is faster than other inhalation anesthesia.

摘要

研究目的

总结并评估现有描述氙气麻醉恢复参数的数据。

设计

系统评价与荟萃分析。

背景

择期手术麻醉。

患者

对来自包括Medline（1964 - 2013年）、Cochrane对照试验中央注册库（CENTRAL，1990 - 2012年）以及谷歌学术（1966 - 2013年）等数据库的随机对照试验（RCT）进行系统评价。

干预措施

在择期手术中给予氙气或其他麻醉剂吸入。

测量指标

恢复参数（恢复时间、睁眼时的警觉/镇静量表评分、按需反应时的脑电双频指数、拔管时间以及定向时间）。

主要结果

11项RCT（N = 661例患者）符合纳入标准。在睁眼时间方面（平均差[MD]，-4.18分钟；95%置信区间[CI]，-5.03至-3.32分钟；P <.00001）、按需反应时间方面（MD，-5.35分钟；95% CI，-6.59至-4.11分钟；P <.00001）、拔管时间方面（MD，-4.49分钟；95% CI，-5.40至-3.58分钟；P <.00001）以及定向时间方面（MD，-4.99分钟；95% CI，-6.45至-3.52分钟；P <.00001），氙气麻醉的恢复明显更快。