Infection and Immunity Program, Monash Biomedicine Discovery Institute and Department of Microbiology, Monash University, Clayton, Victoria, Australia 3800.
Infection and Immunity Program, Monash Biomedicine Discovery Institute and Department of Microbiology, Monash University, Clayton, Victoria, Australia 3800.
Trends Microbiol. 2016 Jun;24(6):463-476. doi: 10.1016/j.tim.2016.02.001. Epub 2016 Feb 17.
Antibiotic-associated diarrhoea (AAD) is a common and unintended consequence of antibiotic use. Clostridium difficile is the most common infectious aetiology of AAD; however, only approximately 25% of all AAD cases are associated with C. difficile infection, with the aetiology in the majority of cases remaining undetermined. Numerous other bacterial infectious agents have been implicated in AAD, including Clostridium perfringens, Staphylococcus aureus, and Klebsiella oxytoca. AAD is a complex disease that is influenced by the host, the infectious agent involved, and numerous clinical factors, including antibiotic treatment regimes. This review re-examines AAD and presents current perspectives on this disease, with a particular focus on the current understanding of bacterial causes other than C. difficile and the virulence factors involved in pathogenesis. VIDEO ABSTRACT.
抗生素相关性腹泻（AAD）是抗生素使用的一种常见且非预期的后果。艰难梭菌是 AAD 最常见的传染性病因；然而，只有大约 25%的所有 AAD 病例与艰难梭菌感染相关，大多数情况下的病因仍未确定。许多其他细菌感染因子也与 AAD 有关，包括产气荚膜梭菌、金黄色葡萄球菌和产酸克雷伯菌。AAD 是一种复杂的疾病，受宿主、涉及的感染因子以及许多临床因素的影响，包括抗生素治疗方案。这篇综述重新审视了 AAD，并介绍了对这种疾病的当前观点，特别关注除艰难梭菌以外的细菌病因和发病机制中涉及的毒力因子的当前理解。视频摘要。
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