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疑似患有抗生素相关性腹泻患者中产气荚膜梭菌毒素的患病率。

Prevalence of Clostridium perfringens toxin in patients suspected of having antibiotic-associated diarrhea.

作者信息

Kim Young Jin, Kim Si Hyun, Ahn Junggu, Cho Soongmoon, Kim Dongchun, Kim Kwanghyun, Lee Heegun, Son Hyunwoo, Lee Hee Joo, Yong Dongeun, Choi Jun Yong, Kim Hye Ran, Shin Jeong Hwan

机构信息

Department of Laboratory Medicine, School of Medicine, Kyung Hee University, Seoul, Republic of Korea.

Department of Laboratory Medicine, Inje University College of Medicine, Busan, Republic of Korea; Paik Institute for Clinical Research, Inje University College of Medicine, Busan, Republic of Korea.

出版信息

Anaerobe. 2017 Dec;48:34-36. doi: 10.1016/j.anaerobe.2017.06.015. Epub 2017 Jun 26.

DOI:10.1016/j.anaerobe.2017.06.015
PMID:28655582
Abstract

BACKGROUND

Although Clostridium perfringens has been reported as a cause of antibiotic-associated diarrhea (AAD), it is uncommon to detect this pathogen in clinical microbiology laboratories in Korea. The aim of this study was to investigate the prevalence of C. perfringens toxin in patients suspected of having AAD.

METHODS

A total of 135 stool specimens submitted to a clinical microbiology laboratory for C. difficile toxin assay were tested. We tried to detect both C. difficile and C. perfringens toxins using the Seeplex Diarrhea ACE Detection kit (Seegene, Seoul, Korea). We evaluated the prevalence of 10 bacteria and 5 viruses.

RESULTS

A total of 40 Clostridium spp. were detected in 34 specimens (29.6%). The C. perfringens toxin was detected in 14 of 135 specimens (10.4%), while C. difficile toxin was detected in 26 specimens (19.3%). Other bacteria and viruses, including 8 Aeromonas spp., were detected in 15 specimens. All tests were negative in 92 of the 135 specimens (68.1%).

CONCLUSION

Clostridium perfringens toxin is relatively common, and we should consider the possibility of its presence in patients suspected of having AAD, especially if C. difficile tests are negative.

摘要

背景

尽管产气荚膜梭菌已被报道为抗生素相关性腹泻（AAD）的病因，但在韩国临床微生物实验室中检测到这种病原体并不常见。本研究的目的是调查疑似患有AAD的患者中产气荚膜梭菌毒素的流行情况。

方法

对提交至临床微生物实验室进行艰难梭菌毒素检测的135份粪便标本进行检测。我们尝试使用Seeplex腹泻ACE检测试剂盒（韩国首尔Seegene公司）检测艰难梭菌毒素和产气荚膜梭菌毒素。我们评估了10种细菌和5种病毒的流行情况。

结果

在34份标本（29.6%）中总共检测到40株梭菌属细菌。在135份标本中的14份（10.4%）检测到产气荚膜梭菌毒素，而在26份标本（19.3%）中检测到艰难梭菌毒素。在15份标本中检测到包括8株气单胞菌属细菌在内的其他细菌和病毒。135份标本中的92份（68.1%）所有检测均为阴性。

结论

产气荚膜梭菌毒素相对常见，对于疑似患有AAD的患者，我们应考虑其存在的可能性，尤其是在艰难梭菌检测结果为阴性时。

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