Wang Lei, Guo Xiu-Li
Department of Pharmacology, School of Pharmaceutical Sciences, Shandong University, Jinan 250012, PR China.
Department of Pharmacology, School of Pharmaceutical Sciences, Shandong University, Jinan 250012, PR China.
Biomed Pharmacother. 2016 Mar;78:165-171. doi: 10.1016/j.biopha.2016.01.014. Epub 2016 Jan 29.
Galectin-3, a multifunctional protein, distributes inside and outside cells and plays an important role in tumor cell adhesion, proliferation, differentiation, angiogenesis, and metastasis in multiple tumors. Changes in galectin-3 expression are commonly seen in cancer and pre-cancerous conditions. Therefore, to understand the molecular regulation of galectin-3 expression could aid the development of new approach for cancer treatment. This review summarizes different expression of galectin-3 in cancer cells and patients' serum, the regulation mechanism and the potential therapeutic targets of galectin-3 in cancer progression.
半乳糖凝集素-3是一种多功能蛋白质，分布于细胞内外，在多种肿瘤的肿瘤细胞黏附、增殖、分化、血管生成和转移中发挥重要作用。半乳糖凝集素-3表达的变化在癌症及癌前病变中普遍可见。因此，了解半乳糖凝集素-3表达的分子调控有助于开发新的癌症治疗方法。本文综述了半乳糖凝集素-3在癌细胞和患者血清中的不同表达、调控机制以及其在癌症进展中的潜在治疗靶点。
