雌激素对微小RNA的抑制作用可能是癌症的一个潜在病因。
Estrogen repression of microRNA as a potential cause of cancer.
作者信息
Cohen Amit, Burgos-Aceves Mario Alberto, Smith Yoav
机构信息
Genomic Data Analysis Unit, The Hebrew University of Jerusalem-Hadassah Medical School, P.O. Box 12272, Jerusalem 91120, Israel.
Centro de Investigaciones Biolόgicas del Noroeste, S.C. Mar Bermejo 195, Col. Playa Palo de Sta. Rita, La Paz, BCS, 23090, México.
出版信息
Biomed Pharmacother. 2016 Mar;78:234-238. doi: 10.1016/j.biopha.2016.01.023. Epub 2016 Feb 2.
MicroRNAs (miRNAs) are endogenous small molecules that regulate gene expression and have been implicated in the pathogenesis of many human diseases, including cancer. This review describes the results that show a global repression in miRNA expression in various tumors and cancer cell lines. Intriguingly, recent discoveries have shown a widespread downregulation of miRNA after exposure to the steroid hormone estrogen. The integration of the results suggests that estrogen-dependent repression of miRNA is a potential cause of cancer.
微小RNA（miRNA）是调节基因表达的内源性小分子，与包括癌症在内的多种人类疾病的发病机制有关。本综述描述了显示各种肿瘤和癌细胞系中miRNA表达整体受到抑制的结果。有趣的是，最近的发现表明，暴露于类固醇激素雌激素后，miRNA普遍下调。这些结果综合起来表明，雌激素依赖性miRNA抑制是癌症的一个潜在原因。
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