Cohen Amit, Burgos-Aceves Mario Alberto, Kahan Tamar, Smith Yoav
Genomic Data Analysis Unit, The Hebrew University of Jerusalem-Hadassah Medical School, P.O. Box 12272, Jerusalem 91120, Israel.
Laboratorio de Endocrinología, Centro de Investigaciones Biológicas del Noroeste, Instituto Politécnico Nacional 195, Playa Palo de Santa Rita Sur, La Paz 23096, B.C.S., Mexico.
Biomedicines. 2017 Aug 14;5(3):47. doi: 10.3390/biomedicines5030047.
Widespread microRNA (miRNA) repression is a phenomenon observed in mammals after exposure to cigarette smoke and in many types of cancer. A comprehensive reduction in miRNA expression after treatment with the hormone estrogen has also previously been described. Here, we reveal a conserved association of miRNA downregulation after estrogen exposure in zebrafish, mouse, and human breast cancer cell line, with a high guanine content in the terminal loop sequences of their precursors, and offer a possible link between estrogen-related miRNA-adducts formation and carcinogenesis. We also show common gene expression patterns shared by breast cancer tumors and estrogen-treated zebrafish, suggesting that this organism can be used as a powerful model system for the study of human breast cancer.
广泛的微小RNA（miRNA）抑制是在哺乳动物接触香烟烟雾后以及在许多类型癌症中观察到的一种现象。此前也有关于用雌激素处理后miRNA表达全面降低的描述。在这里，我们揭示了斑马鱼、小鼠和人乳腺癌细胞系在雌激素暴露后miRNA下调的保守关联，其前体的末端环序列中鸟嘌呤含量较高，并提出了雌激素相关miRNA加合物形成与致癌作用之间可能的联系。我们还展示了乳腺癌肿瘤和雌激素处理的斑马鱼共有的常见基因表达模式，表明这种生物体可作为研究人类乳腺癌的强大模型系统。
